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Beclin 1 抗体 (AA 1-354)

BECN1 适用: 人, 小鼠, 大鼠 WB, IF, FACS, ICC, IP 宿主: 兔 Polyclonal unconjugated

Western Blotting (WB) image for anti-Beclin 1, Autophagy Related (BECN1) (AA 1-354) antibody (ABIN3042322) (Beclin 1 抗体 (AA 1-354))

Anti-Beclin 1 Picoband antibody, IHC(P): Rat Spleen Tissue (Beclin 1 抗体 (AA 1-354))

Anti-Beclin 1 Picoband antibody, IHC(P): Rat Intestine Tissue (Beclin 1 抗体 (AA 1-354))

Anti-Beclin 1 Picoband antibody, IHC(P): Mouse Intestine Tissue (Beclin 1 抗体 (AA 1-354))

Anti-Beclin 1 Picoband antibody, IHC(P): Mouse Spleen Tissue (Beclin 1 抗体 (AA 1-354))

5 images

(7 references)

产品编号 ABIN3042322

发货至: 中国

Datasheet as PDF

抗原 See all Beclin 1 (BECN1) 抗体

Beclin 1 (BECN1) (Beclin 1, Autophagy Related (BECN1))
抗原表位
15

15

11

8

8

7

6

6

6

6

6

5

4

4

4

3

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 1-354
适用
175

72

58

6

6

5

4

3

3

3

2

1

1

1
人, 小鼠, 大鼠
宿主
134

49

2

1
兔
Compatible Secondaries
克隆类型
131

55
多克隆
标记
107

13

10

9

8

8

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1
This Beclin 1 antibody is un-conjugated
应用范围
147

80

68

37

33

29

25

23

19

17

12

3

2

2
Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunoprecipitation (IP)

原理

Anti-Beclin 1/BECN1 Antibody Picoband®

交叉反应（详细）

No cross-reactivity with other proteins

产品特性

Anti-Beclin 1/BECN1 Antibody Picoband® (ABIN3042322). Tested in Flow Cytometry, IP, IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

纯化方法

Immunogen affinity purified.

免疫原

E.coli-derived human Beclin 1 recombinant protein (Position: M1-S354). Human Beclin 1 shares 97% amino acid (aa) sequence identity with both mouse and rat Beclin 1.

亚型

IgG

Top Product

Discover our top product BECN1 Primary Antibody
anti-Beclin 1, Autophagy Related (BECN1) (AA 201-330) antibody
BECN1 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, ICC, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Beclin 1, Autophagy Related (BECN1) antibody
BECN1 适用: 人, 大鼠, 犬 WB, IHC, IF, FACS, IHC (p) 宿主: 小鼠 Monoclonal 1F1 unconjugated

anti-Beclin 1, Autophagy Related (BECN1) antibody
BECN1 适用: 人, 大鼠, 猴 WB, IHC, IF, FACS, IHC (p) 宿主: 小鼠 Monoclonal 3F3 unconjugated

anti-Beclin 1, Autophagy Related (BECN1) antibody
BECN1 适用: 人, 大鼠, 猴, 犬 WB, IHC, IF, FACS, IHC (p) 宿主: 小鼠 Monoclonal 3C3 unconjugated

anti-Beclin 1, Autophagy Related (BECN1) antibody
BECN1 适用: 人 WB, ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 2A4 unconjugated

anti-Beclin 1, Autophagy Related (BECN1) (AA 210-239) antibody
BECN1 适用: 人, 小鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB7463 unconjugated

anti-Beclin 1, Autophagy Related (BECN1) (AA 210-239) antibody
BECN1 适用: 人, 小鼠 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated

anti-Beclin 1, Autophagy Related (BECN1) (C-Term) antibody
BECN1 适用: 人, 小鼠 WB, ELISA, IHC, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Beclin 1, Autophagy Related (BECN1) (AA 181-210) antibody
BECN1 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Beclin 1, Autophagy Related (BECN1) (AA 95-132) antibody
BECN1 适用: 人, 小鼠 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated

应用备注

Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Immunoprecipitation, 0.5-2 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
1. Liang, X. H., Kleeman, L. K., Jiang, H. H., Gordon, G., Goldman, J. E., Berry, G., Herman, B., Levine, B.Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein. J. Virol. 72: 8586-8596, 1998. 2. Merenlender-Wagner A, Malishkevich A, Shemer Z, Udawela M, Gibbons A, Scarr E, Dean B, Levine J, Agam G, Gozes I (December 2013). "Autophagy has a key role in the pathophysiology of schizophrenia". Mol. Psychiatry.

说明

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

限制

仅限研究用
状态

Lyophilized

溶解方式

Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

浓度

500 μg/mL

缓冲液

Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C,-20 °C

储存方法

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Song, Hu, Li, Zheng, Wang, Guo, Shi, Liu: "Suppression of the toll-like receptor 7-dependent type I interferon production pathway by autophagy resulting from enterovirus 71 and coxsackievirus A16 infections facilitates their replication." in: Archives of virology, Vol. 163, Issue 1, pp. 135-144, (2018) (PubMed).

Wang, Dai, Song, Zhu, Liu, Hou, Ke, Zhou, Qiu, Wang, Jiang, Jia, Feng: "Lactone Component From Ligusticum chuanxiong Alleviates Myocardial Ischemia Injury Through Inhibiting Autophagy." in: Frontiers in pharmacology, Vol. 9, pp. 301, (2018) (PubMed).

Qi, Xue, Lv, Sun, Du, Cai, Li, Gu, Wang: "Ginkgolic acids induce HepG2 cell death via a combination of apoptosis, autophagy and the mitochondrial pathway." in: Oncology letters, Vol. 15, Issue 5, pp. 6400-6408, (2018) (PubMed).

Shen, Cai, Liu, Li, Gan, Li, Wang, Guo, Zhou, Lu, Sun, Li: "Ube2v1-mediated ubiquitination and degradation of Sirt1 promotes metastasis of colorectal cancer by epigenetically suppressing autophagy." in: Journal of hematology & oncology, Vol. 11, Issue 1, pp. 95, (2018) (PubMed).

Wang, Ma, Hu, Xie, Wu, Zeng, Song: "Bifidobacterial recombinant thymidine kinase-ganciclovir gene therapy system induces FasL and TNFR2 mediated antitumor apoptosis in solid tumors." in: BMC cancer, Vol. 16, pp. 545, (2017) (PubMed).

Sun, Gao, Meng, Xu, Wang, Gu, Guo, Shao, Yan, Jiang, Zheng: "Antagomirs Targeting MiroRNA-134 Attenuates Epilepsy in Rats through Regulation of Oxidative Stress, Mitochondrial Functions and Autophagy." in: Frontiers in pharmacology, Vol. 8, pp. 524, (2017) (PubMed).

Bu, Zhao, Zhang, Wang, Li, Yan: "Recombinant Newcastle disease virus (rL-RVG) triggers autophagy and apoptosis in gastric carcinoma cells by inducing ER stress." in: American journal of cancer research, Vol. 6, Issue 5, pp. 924-36, (2016) (PubMed).
抗原

Beclin 1 (BECN1) (Beclin 1, Autophagy Related (BECN1))

别名

BECN1 (BECN1 产品)

背景

Synonyms: Beclin-1,Coiled-coil myosin-like BCL2-interacting protein,Protein GT197,BECN1,GT197,
Tissue Specificity: Ubiquitous.
Background: Beclin-1, also known as also known as ATG6 or VPS30 is a protein that in humans is encoded by the BECN1 gene. Beclin-1 and its binding partner class III phosphoinositide 3-kinase (PI3K), also named Vps34, are required for the initiation of the formation of the autophagosome in autophagy. This gene participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration. Schizophrenia is associated with low levels of Beclin-1 in the hippocampus of the affected which causes diminished autophagywhich in turn results in increased neuronal cell death. It has been found that beclin-1 can promote autophagy in autophagy-defective yeast with a targeted disruption of apg6/vps30, and in human MCF7 breast carcinoma cells.
Sequence Similarities: Belongs to the lipoxygenase family.

分子量

60 kDa

基因ID

8678

UniProt

Q14457

途径

Autophagy

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