TRIM5 抗体 (N-Term)
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- 抗原 See all TRIM5 抗体
- TRIM5 (Tripartite Motif Containing 5 (TRIM5))
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抗原表位
- N-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This TRIM5 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 纯化方法
- Immunoaffinity Chromatography.
- 免疫原
- Synthetic Peptide corresponding to Amino Acids near the mid-region of human TRIM5a.
- Top Product
- Discover our top product TRIM5 Primary Antibody
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anti-Tripartite Motif Containing 5 (TRIM5) (N-Term) antibody
Verified TRIM5 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Tripartite Motif Containing 5 (TRIM5) (N-Term) antibodyTRIM5 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Tripartite Motif Containing 5 (TRIM5) antibodyTRIM5 适用: 人 WB, ELISA, IHC 宿主: 小鼠 Monoclonal 3B11H2 unconjugated
anti-Tripartite Motif Containing 5 (TRIM5) (AA 1-493) antibodyTRIM5 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Tripartite Motif Containing 5 (TRIM5) antibodyTRIM5 适用: 人, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Tripartite Motif Containing 5 (TRIM5) (AA 100-200) antibodyTRIM5 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Tripartite Motif Containing 5 (TRIM5) (N-Term) antibodyTRIM5 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Tripartite Motif Containing 5 (TRIM5) (truncated) antibodyTRIM5 适用: 人 WB, IHC 宿主: 小鼠 Monoclonal 3B11H2 unconjugated
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- 应用备注
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Immunohistochemistry on Paraffin Sections (5 μg/mL). Immunohistochemistry (2 μg/mL). Western Blot (5 μg/mL).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 浓度
- 1.0 mg/mL
- 缓冲液
- Phosphate Buffered Saline PBS containing 0.02 % Sodium Azide as preservative.
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer. Dilute only prior to immediate use.
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- 抗原
- TRIM5 (Tripartite Motif Containing 5 (TRIM5))
- 别名
- TRIM5 / RNF88 (TRIM5 产品)
- 背景
- TRIM5 is a member of a broad family of otherwise unrelated proteins defined by the presence of a tripartite motif containing a RING domain, a B-box type 1, and a B-box type 2, followed by a coiled-coil region. TRIM5 has six alternately spliced isoforms, the longest of which is the a variant which also contains a carboxy-terminal B30.2 (SPRY) domain. Expression of TRIM5a variants from humans, rhesus monkeys, and African green monkeys enabled resistance to infection by various retroviruses including HIV-1, albeit at differing efficiencies. All TRIM5a variants could inhibit at least two different retroviruses, but not from those viruses isolated from the same species, suggesting that TRIM5a acts as a natural barrier to cross-species retrovirus transmission. While a function has not yet been assigned to TRIM5g, it is known that expression of TRIM5a variants from humans, rhesus monkeys, and African green monkeys enable resistance to infection by various retroviruses including HIV-1, albeit at differing efficiencies. Furthermore, the TRIM5d isoform appears to serve as a scaffold for the assembly of endogenous BTBD1 and BTBD2 proteins and also exhibits autoubiquitination activity in a RING finger- and UbcH5B-dependent manner. The TRIM5d isoform has been shown to colocalize with the topoisomerase I-interacting proteins BTBD1 and BTBD2 in punctate or elongated cytoplasmic bodies in several mouse and human cells where it appears to serve as a scaffold for the assembly of endogenous BTBD proteins. TRIM5d also exhibits autoubiquitination activity in a RING finger- and UbcH5B-dependent manner.Synonyms: RING finger protein 88, Tripartite motif-containing protein 5
- 基因ID
- 85363
- NCBI登录号
- NP_149023
- UniProt
- Q9C035
- 途径
- Activation of Innate immune Response
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