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ERK1/2 抗体 (N-Term)

MAPK1/3 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN3031825
发货至: 中国
  • 抗原 See all ERK1/2 (MAPK1/3) 抗体
    ERK1/2 (MAPK1/3) (Mitogen-Activated Protein Kinase 1/3 (MAPK1/3))
    抗原表位
    • 49
    • 41
    • 30
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    N-Term
    适用
    • 192
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    人, 小鼠, 大鼠
    宿主
    • 143
    • 51
    • 4
    克隆类型
    • 139
    • 59
    多克隆
    标记
    • 97
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    This ERK1/2 antibody is un-conjugated
    应用范围
    • 155
    • 65
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    • 37
    • 25
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    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    纯化方法
    Antigen affinity
    免疫原
    An amino acid sequence from the N-terminus of human MAPK1/3 (ARVADPDHDHTGFL) was used as the immunogen for this MAPK1/3 antibody (100% homologous in human, mouse and rat).
    亚型
    IgG
    Top Product
    Discover our top product MAPK1/3 Primary Antibody
  • 应用备注
    The stated application concentrations are suggested starting amounts. Titration of the MAPK1/3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL
    限制
    仅限研究用
  • 缓冲液
    0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
    储存条件
    -20 °C
    储存方法
    After reconstitution, the MAPK1/3 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
  • 抗原
    ERK1/2 (MAPK1/3) (Mitogen-Activated Protein Kinase 1/3 (MAPK1/3))
    别名
    MAPK1/3 (MAPK1/3 产品)
    别名
    erk1/2 antibody, mitogen-activated protein kinase antibody, erk1/2 antibody
    背景
    MAPK1(ERK2) shares high homology with MAPK3(ERK1). MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network. Mitogen-activated protein(MAP) kinases [also known as Erks] have been established to function as important mediators of signal transduction by growth factor receptors. ERK1/ERK2-dependent activation of endogenous ribosomal transcription, while inactivation of ERK1/ERK2 causes an equally immediate reversion to the basal transcription level. ERK1/ERK2 was found to phosphorylate the architectural transcription factor UBF at amino acids 117 and 201 within HMG boxes 1 and 2, preventing their interaction with DNA. Mutation of these sites inhibited transcription activation and abrogated the transcriptional response to ERK1/ERK2.
    UniProt
    P28482
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