BMI1 抗体
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北京 101111
Quick Overview for BMI1 抗体 (ABIN303071)
抗原
See all BMI1 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody reacts to DNA-binding protein Bmi-1.
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纯化方法
- Immunoaffinity Chromatography
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免疫原
- Synthetic peptide
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anti-BMI1 Polycomb Ring Finger Oncogene (BMI1) antibody
BMI1 适用: 人 IHC, ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 3E3 unconjugated
anti-BMI1 Polycomb Ring Finger Oncogene (BMI1) antibodyBMI1 适用: 人, 小鼠 WB, IF, IHC (p), FACS 宿主: 兔 Polyclonal RB22858 unconjugated
anti-BMI1 Polycomb Ring Finger Oncogene (BMI1) (AA 250-300) antibodyBMI1 适用: 人, 小鼠 WB, IHC, ICC, IP, FACS 宿主: 兔 Monoclonal BLR119H unconjugated Recombinant Antibody
anti-BMI1 Polycomb Ring Finger Oncogene (BMI1) (AA 142-326) antibodyBMI1 适用: 人, 小鼠 WB, IHC, IF 宿主: 小鼠 Monoclonal BMI1-2823 unconjugated
anti-BMI1 Polycomb Ring Finger Oncogene (BMI1) (AA 120-326) antibodyBMI1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-BMI1 Polycomb Ring Finger Oncogene (BMI1) (AA 142-326) antibodyBMI1 适用: 人 WB, IHC 宿主: 小鼠 Monoclonal BMI1-2689 unconjugated
anti-BMI1 Polycomb Ring Finger Oncogene (BMI1) (AA 1-326) antibodyBMI1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4E10-1C5 unconjugated
anti-BMI1 Polycomb Ring Finger Oncogene (BMI1) (AA 142-326) antibodyBMI1 适用: 人 IHC 宿主: 小鼠 Monoclonal BMI1-2690 unconjugated
anti-BMI1 Polycomb Ring Finger Oncogene (BMI1) antibodyKD Validated BMI1 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB685 unconjugated Recombinant Antibody
anti-BMI1 Polycomb Ring Finger Oncogene (BMI1) (AA 257-286), (C-Term) antibodyBMI1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB02926 unconjugated
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应用备注
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Immunohistochemistry on paraffin sections: 2,5 μg/mL. Western Blot: 1: 500 - 1: 3000. ELISA: 1: 5000 - 30000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 0.9 mg/mL
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缓冲液
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 with 0.01 % (w/v) Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
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- BMI1 (BMI1 Polycomb Ring Finger Oncogene (BMI1))
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别名
- BMI-1 / RNF51
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背景
- The Bmi-1 oncogene (also known as polycomb group ring finger 4, MGC12685, murine leukemia viral (bmi 1) oncogene homolog, oncogene BMI 1, polycomb complex protein BMI 1 and RNF51) induces telomerase activity and immortalizes human mammary epithelial cells. Bmi-1 extends the replicative life span of human fibroblasts by suppressing the p16-dependent senescence pathway. The polycomb group (PcG) genes are involved in the maintenance of cellular memory through epigenetic chromatin modifications. Recent studies have implicated a role for PcG genes in the self-renewal of hematopoietic stem cells (HSCs), a process in which cellular memory is maintained through cell division. Among the PcG genes, Bmi-1 plays a central role in the inheritance of stemness, and its forced expression promotes HSC self-renewal. These findings highlight the importance of epigenetic regulation in HSC self-renewal and identify PcG genes as potential targets for therapeutic HSC manipulation.Synonyms: BMI1, PCGF4, Polycomb group RING finger protein 4, RING finger protein 51
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基因ID
- 100532731
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NCBI登录号
- NP_001190991
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UniProt
- P35226
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途径
- Cell Division Cycle, Autophagy
抗原
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