CISH 抗体 (AA 241-258)
Quick Overview for CISH 抗体 (AA 241-258) (ABIN3030694)
抗原
See all CISH 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 241-258
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纯化方法
- Antigen affinity
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免疫原
- Amino acids 241-258 (LPLPRRMADYLRQYPFQL) were used as the immunogen for this CISH antibody (100% homologous in human, mouse and rat).
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亚型
- IgG
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anti-Cytokine Inducible SH2-Containing Protein (CISH) (C-Term) antibody
CISH 适用: 人 WB, ICC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cytokine Inducible SH2-Containing Protein (CISH) (AA 1-258) antibodyCISH 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Cytokine Inducible SH2-Containing Protein (CISH) (AA 1-258) antibodyCISH 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Cytokine Inducible SH2-Containing Protein (CISH) (AA 1-258) antibodyCISH 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cytokine Inducible SH2-Containing Protein (CISH) (AA 79-256) antibodyCISH 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cytokine Inducible SH2-Containing Protein (CISH) (AA 1-257) antibodyCISH 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Cytokine Inducible SH2-Containing Protein (CISH) (AA 17-130) antibodyCISH 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Cytokine Inducible SH2-Containing Protein (CISH) (AA 241-258), (C-Term) antibodyCISH 适用: 人, 小鼠, 大鼠 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cytokine Inducible SH2-Containing Protein (CISH) (AA 78-127) antibodyCISH 适用: 人, 小鼠, 大鼠, Pig, Cow, 马, 兔, 犬, Bat, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Cytokine Inducible SH2-Containing Protein (CISH) antibodyCISH 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- The stated application concentrations are suggested starting amounts. Titration of the CISH antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL,Immunocytochemistry: 0.5-1 μg/mL
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限制
- 仅限研究用
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- -20 °C
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储存方法
- After reconstitution, the CISH antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
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- CISH (Cytokine Inducible SH2-Containing Protein (CISH))
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别名
- CISH
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背景
- Cytokine inducible SH2-containing protein, also called CIS, CIS-1, G18, SOCS, is an important negative regulator for inflammatory signaling and belongs to the suppressors of cytokine signaling (SOCS) family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. CISH controls interleukin-2 signaling, and variations of CISH with certain SNPs are associated with susceptibility to bacteremia, tuberculosis and malaria. The human gene is mapped to chromosome 3p21.3 by FISH. The mouse gene is tightly linked to the Gnai2 gene on chromosome 9, a region syntenic to human chromosome 3p21. CISH expression was upregulated by lipopolysaccharide (LPS) or Cryptosporidium parvum exposure, and this upregulation involved downregulation of MIR98 and LET7, which relieved MIR98- and LET7-mediated translational repression of CISH. Gain- and loss-of-function studies showed that CISH accelerated degradation of IKBA and enhanced NFKB activation in cholangiocytes in response to LPS stimulation or C parvum exposure.
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UniProt
- Q9NSE2
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途径
- JAK/STAT Signaling, Response to Growth Hormone Stimulus
抗原
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