BRCA1 抗体 (AA 1661-1863)
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北京 101111
Quick Overview for BRCA1 抗体 (AA 1661-1863) (ABIN3030202)
抗原
See all BRCA1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1661-1863
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纯化方法
- Antigen affinity
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免疫原
- Human partial recombinant protein (AA 1661-1863) was used as the immunogen for this BRCA1 antibody.
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亚型
- IgG
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anti-Breast Cancer 1 (BRCA1) (AA 120-220) antibody
BRCA1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Breast Cancer 1 (BRCA1) (AA 19-83) antibodyBRCA1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Breast Cancer 1 (BRCA1) (pSer1423) antibodyBRCA1 适用: 人, 大鼠, 小鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Breast Cancer 1 (BRCA1) (AA 229-335) antibodyBRCA1 适用: 人 IHC, ELISA 宿主: 小鼠 Monoclonal 6C6D2 unconjugated
anti-Breast Cancer 1 (BRCA1) (AA 1661-1863) antibodyBRCA1 适用: 人, 大鼠, 小鼠 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Breast Cancer 1 (BRCA1) (Ser184), (Ser186) antibodyBRCA1 适用: 人, 大鼠 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Breast Cancer 1 (BRCA1) (AA 445-620) antibodyBRCA1 适用: 人 IHC, ISt, StM 宿主: 小鼠 Monoclonal BRCA1-1398 unconjugated
anti-Breast Cancer 1 (BRCA1) (AA 1314-1600), (AA 1314-1864) antibodyBRCA1 适用: 人 WB, IF, IP, FACS, ICC 宿主: 小鼠 Monoclonal RAY unconjugated
anti-Breast Cancer 1 (BRCA1) (AA 64-160) antibodyBRCA1 适用: 大鼠, 小鼠 ELISA, IHC (p), IF (p), FACS, IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Breast Cancer 1 (BRCA1) (pSer1524) antibodyBRCA1 适用: 人 ELISA, FACS 宿主: 兔 Polyclonal unconjugated
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应用备注
- The stated application concentrations are suggested starting points. Titration of the BRCA1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL
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限制
- 仅限研究用
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- -20 °C
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储存方法
- After reconstitution, the BRCA1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
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- BRCA1 (Breast Cancer 1 (BRCA1))
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别名
- BRCA1
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背景
- The BRCA1 gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). BRCA1 product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. In addition to it, it may normally serve as a negative regulator of mammary epithelial cell growth and that this function is compromised in breast cancer either by direct mutation or by alterations in gene expression.
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基因ID
- 672
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途径
- Cell Division Cycle, DNA Damage Repair, Intracellular Steroid Hormone Receptor Signaling Pathway, Positive Regulation of Response to DNA Damage Stimulus
抗原
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