XBP1 抗体 (C-Term)
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Quick Overview for XBP1 抗体 (C-Term) (ABIN302900)
抗原
See all XBP1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- This antibody reacts to a 17 amino acid peptide from near the carboxy terminus of XBP-1.
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纯化方法
- Immunoaffinity Chromatography.
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免疫原
- Synthetic peptide corresponding to a 17 amino acid peptide from near the Carboxy terminus of XBP-1.
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应用备注
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Immunohistochemistry on Paraffin Sections: 5 μg/mL. Western Blot: 1-2 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Phosphate buffered saline, containing 0.02 % Sodium Azide as preservative.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or in (aliquots) at-20 °C for longer.
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- XBP1 (X-Box Binding Protein 1 (XBP1))
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别名
- XBP1 / TREB5
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背景
- This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. The protein contains two domains commonly found in transcription factors that confer DNA binding and dimerization capability. This gene product was also separately identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. There is also a recent finding that the same agents that cause an ER stress response, the unfolded protein response, also increase transcription of this gene. This increase in transcription requires an ER stress response consensus binding element in the promoter.Synonyms: Tax-responsive element-binding protein 5, X-box-binding protein 1, XBP-1, XBP2
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基因ID
- 7494
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NCBI登录号
- NP_001073007
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UniProt
- P17861
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途径
- ER-Nucleus Signaling, Unfolded Protein Response
抗原
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