TIMD4 抗体 (Center)
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Quick Overview for TIMD4 抗体 (Center) (ABIN302874)
抗原
See all TIMD4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Center
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特异性
- This antibody recognizes T-cell Immunoglobulin And Mucin Domain Containing 4 (TIMD4)
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纯化方法
- Immunoaffinity Chromatography.
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免疫原
- Synthetic peptide - KLH conjugated corresponding to a 16 amino acid peptide from near the center of Human TIM-4
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应用备注
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Western Blot: 1-2 μg/mL. Immunocytochemistry. Immunohistochemistry on Paraffin Sections: 5 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- PBS containing 0.02 % Sodium Azide as preservative.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or in aliquots at-20 °C for longer.
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- TIMD4 (T-Cell Immunoglobulin and Mucin Domain Containing 4 (TIMD4))
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别名
- TIMD4
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背景
- The T cell immunoglobulin and mucin domain containing protein (TIM) family encodes cell surface receptors that are involved in the regulation of T helper (Th) -1 and -2 cell-mediated immunity. Studies have shown that TIM 4, which is preferentially expressed on macrophages and dendritic cells, is the natural ligand of TIM 1, and that this binding leads to T-cell expansion and cytokine production. Unlike other members of the TIM family, TIM 4 lacks a putative tyrosine phosphorylation signal sequence in its intracellular domain (Kuchroo et al, 2003). The TIM 4 gene maps to a locus associated with predisposition to asthma in both mice and humans and with its connection to TIM 1-triggered Th2 responsiveness, may be considered as a candidate disease/predisposition gene for asthma (Shakhov et al 2004).Synonyms: T-cell immunoglobulin and mucin domain-containing protein 4, T-cell membrane protein 4, TIM-4, TIM4, TIMD-4
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基因ID
- 91937
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NCBI登录号
- NP_001140198
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UniProt
- Q96H15
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途径
- Cancer Immune Checkpoints
抗原
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