CD46 抗体
Quick Overview for CD46 抗体 (ABIN3025892)
抗原
See all CD46 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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无交叉反应
- 马
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纯化方法
- Protein G affinity chromatography
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免疫原
- Stimulated human leukocytes were used as the immunogen for the CD46 antibody.
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亚型
- IgG2a kappa
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应用备注
- Optimal dilution of the CD46 antibody should be determined by the researcher.\. Flow Cytometry: 0.5-1 μg/million cells in 0.1ml,Immunofluorescence: 0.5-1 μg/mL
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- 4 °C,-20 °C
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储存方法
- Store the CD46 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
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- CD46
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别名
- CD46
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背景
- Recognizes a protein of 52 kDa-58 kDa, identified as CD46 (also known as membrane cofactor protein, MCP). Its epitope is located on the four immunogenic short consensus repeat (SCR) domains at N-terminus of the protein. CD46 exists as many isoforms in a variety of tissues. It is strongly expressed on salivary gland ducts and kidney ducts, moderately on lymphocytes and endothelium, and weakly on interstitial tissues and muscle cells, but not on erythrocytes. CD46 functions as a C3b/C4b-binding glycoprotein that inhibits complement activation on host cells. It also serves as a measles virus receptor, an adherence factor for group A Streptococcus pyogenes, and a cellular pilus receptor for pathogenic Neisseria.
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途径
- Regulation of Actin Filament Polymerization
抗原
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