PDGFB 抗体 (AA 20-241)
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北京 101111
Quick Overview for PDGFB 抗体 (AA 20-241) (ABIN3021689)
抗原
See all PDGFB 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 20-241
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序列
- AEGDPIPEEL YEMLSDHSIR SFDDLQRLLH GDPGEEDGAE LDLNMTRSHS GGELESLARG RRSLGSLTIA EPAMIAECKT RTEVFEISRR LIDRTNANFL VWPPCVEVQR CSGCCNNRNV QCRPTQVQLR PVQVRKIEIV RKKPIFKKAT VTLEDHLACK CETVAAARPV TRSPGGSQEQ RAKTPQTRVT IRTVRVRRPP KGKHRKFKHT HDKTALKETL GA
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交叉反应
- 人, 大鼠
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产品特性
- Polyclonal Antibodies
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免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 20-241 of human PDGFB (NP_002599.1).
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亚型
- IgG
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应用备注
- WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid freeze / thaw cycles
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- PDGFB (Platelet Derived Growth Factor Subunit B (PDGFB))
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别名
- PDGFB
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背景
- This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit B, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit A. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with dermatofibrosarcoma protuberans, a rare skin tumor. Alternative splicing results in multiple transcript variants.,PDGFB,IBGC5,PDGF-2,PDGF2,SIS,SSV,c-sis,Cancer,Signal Transduction,Cell Biology & Developmental Biology,Growth factor,Endocrine & Metabolism,Immunology & Inflammation,Cytokines,Cardiovascular,Angiogenesis,Blood,Serum Proteins,Hypoxia,Heart,Cardiovascular diseases,Heart disease,PDGFB
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分子量
- 25 kDa/27 kDa
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基因ID
- 5155
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UniProt
- P01127
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途径
- RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Carbohydrate Metabolic Process, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling
抗原
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