ABCB1 抗体
Quick Overview for ABCB1 抗体 (ABIN2967168)
抗原
See all ABCB1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Anti-Hu CD243 Purified Low Endotoxin
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特异性
- The mouse monoclonal antibody UIC2 recognizes an extracellular epitope on CD243 (MDR-1), an approximately 170 kDa ABC transporter expressed on hematopoietic stem cells, B, T, and NK cells, or on many multidrug resistant cancer cells. This antibody preferentially recognizes CD243 in the process of transporting substrate.
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无交叉反应
- 小鼠, 大鼠
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交叉反应 （详细）
- Human
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纯化方法
- Purified by protein-A affinity chromatography.
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纯度
- > 95 % (by SDS-PAGE)
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内毒素水平
- Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test.
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免疫原
- NIH 3T3 cells transfected with human CD243 (MDR-1) cDNA
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亚型
- IgG2a kappa
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anti-ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) (AA 621-650), (Middle Region) antibody
ABCB1 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) (AA 995-1280) antibodyABCB1 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 2C7 unconjugated
anti-ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) (AA 995-1280) antibodyABCB1 适用: 人 IHC, IHC (p) 宿主: 小鼠 Monoclonal 5B3 unconjugated
anti-ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) antibodyABCB1 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) (AA 236-297) antibodyABCB1 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) (AA 1149-1280) antibodyABCB1 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 4G6F4 unconjugated
anti-ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) (AA 632-693) antibodyABCB1 适用: 人 ELISA 宿主: 小鼠 Monoclonal 6G11C12 unconjugated
anti-ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) (AA 863-912) antibodyABCB1 适用: 人, 小鼠, 大鼠, 兔, Hamster WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) (Middle Region) antibodyABCB1 适用: 人, 小鼠, 大鼠, 犬, 兔, 马, 斑马鱼, 绵羊, Pig, 豚鼠, Cow WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) (AA 995-1280) antibodyABCB1 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 6H2 unconjugated
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应用备注
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Functional application: inhibition.
Immunohistochemistry (paraffin sections): Heat mediated antigen retrieval in citrate buffer pH 6.
Flow cytometry: Recommended dilution: 1-4 μg/mL -
限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH 7.4
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储存条件
- 4 °C
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储存方法
- Store at 2-8°C. Do not freeze.
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- ABCB1 (ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1))
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别名
- CD243
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背景
- ATP binding cassette subfamily B member 1,CD243, also known as multidrug resistant protein 1 (MDR-1) or P-glycoprotein (Pgp) is an ATP binding cassette (ABC)-containing efflux transporter for xenobiotic lipophilic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. It is expressed in many tissues, including the brain, liver, pancreas, testes, kidney, and blood (B, T, NK cells, but not monocytes).,P-Glycoprotein, CLCS, MDR1, PGY1, ABC20, GP170, ABCB1, ABC transporter
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基因ID
- 5243
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UniProt
- P08183
抗原
-
