Ret Proto-Oncogene 抗体 (Extracellular Domain)
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Quick Overview for Ret Proto-Oncogene 抗体 (Extracellular Domain) (ABIN289533)
抗原
See all Ret Proto-Oncogene (RET) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Extracellular Domain
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纯化方法
- Purified
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免疫原
- Ret antibody was raised in goat using NSO derived murine ret extracellular domain as the immunogen.
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anti-Ret Proto-Oncogene (RET) (AA 702-848) antibody
RET 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal RET-2795 unconjugated
anti-Ret Proto-Oncogene (RET) (AA 1-1072) antibodyRET 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-Ret Proto-Oncogene (RET) (AA 702-848) antibodyRET 适用: 人 ELISA, Coat 宿主: 小鼠 Monoclonal RET-2663 unconjugated
anti-Ret Proto-Oncogene (RET) (AA 541-553), (Extracellular) antibodyRET 适用: 人 WB, IHC, IF, FACS, IC, LCI 宿主: 兔 Polyclonal unconjugated
anti-Ret Proto-Oncogene (RET) (pTyr1062) antibodyRET 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ret Proto-Oncogene (RET) (C-Term) antibodyRET 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ret Proto-Oncogene (RET) (AA 361-458) antibodyRET 适用: 人 WB, ELISA, PLA 宿主: 小鼠 Monoclonal 1A5 unconjugated
anti-Ret Proto-Oncogene (RET) (pTyr905) antibodyRET 适用: 人, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Ret Proto-Oncogene (RET) (AA 1001-1114) antibodyRET 适用: 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Ret Proto-Oncogene (RET) (AA 29-300) antibodyRET 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA: 0.5-1 μg/mL, IHC-F: 5 μg/mL, IHC-P: 10-15 μg/mL, WB: 0.1-0.2 μg/mL
Optimal conditions should be determined by the investigator. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Reconstitute with PBS.
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浓度
- Lot specific
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缓冲液
- Lyophilized from PBS, pH 7.2 containing 5 % trehalose.
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注意事项
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Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use. -
储存条件
- -80 °C
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储存方法
- Aliquot and store at -70 °C or lower.
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: "Distinct adhesion-independent functions of β-catenin control stage-specific sensory neurogenesis and proliferation." in: BMC biology, Vol. 13, pp. 24, (2015) (PubMed).
: "Pro-survival role for Parkinson's associated gene DJ-1 revealed in trophically impaired dopaminergic neurons." in: PLoS biology, Vol. 8, Issue 4, pp. e1000349, (2010) (PubMed).
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: "Distinct adhesion-independent functions of β-catenin control stage-specific sensory neurogenesis and proliferation." in: BMC biology, Vol. 13, pp. 24, (2015) (PubMed).
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- Ret Proto-Oncogene (RET)
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别名
- Ret
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背景
- The Ret proto-oncogene (c-Ret) is a receptor tyrosine kinase that functions as a multicompetent receptor complex in conjunction with other membrane-bound ligand-binding GDNF family receptors. Ligands that bind the Ret receptor include the glial cell line-derived neurotropic factor (GDNF) and its congeners neurturin, persephin and artemin. Alterations in the corresponding Ret gene are associated with diseases including papillary thyroid carcinoma, multiple endocrine neoplasia (type 2A and 2B), familial medullary thyroid carcinoma and a congenital developmental disorder known as Hirschsprung’s disease. The Tyr905 residue located in the Ret kinase domain plays a crucial role in Ret catalytic and biological activity. Substitution of Phe for Tyr905 dramatically inhibits Ret autophosphorylation activity.
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途径
- RTK signaling, Dopaminergic Neurogenesis, Regulation of Cell Size, Tube Formation
抗原
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