BTRC 抗体
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北京 101111
Quick Overview for BTRC 抗体 (ABIN2855453)
抗原
See all BTRC 抗体适用
宿主
克隆类型
标记
应用范围
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交叉反应
- 人, 大鼠
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产品特性
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Rabbit polyclonal antibody to beta-TrCP (beta-transducin repeat containing)
beta-TrCP antibody [N1C1] -
纯化方法
- Purified by antigen-affinity chromatography.
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免疫原
- Recombinant protein encompassing a sequence within the center region of human beta-TrCP. The exact sequence is proprietary.
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亚型
- IgG
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anti-beta-Transducin Repeat Containing (BTRC) (AA 24-151) antibody
BTRC 适用: 人 WB, ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 4C5D8 unconjugated
anti-beta-Transducin Repeat Containing (BTRC) (AA 50-340) antibodyBTRC 适用: 人 WB, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-beta-Transducin Repeat Containing (BTRC) (AA 397-448) antibodyBTRC 适用: 人 WB, ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-beta-Transducin Repeat Containing (BTRC) (N-Term) antibodyBTRC 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-beta-Transducin Repeat Containing (BTRC) (AA 1-605) antibodyBTRC 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-beta-Transducin Repeat Containing (BTRC) (AA 52-354) antibodyBTRC 适用: 人 WB, IF, FACS 宿主: 小鼠 Monoclonal 2H2 unconjugated
anti-beta-Transducin Repeat Containing (BTRC) (AA 17-52), (N-Term) antibodyBTRC 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB16275 unconjugated
anti-beta-Transducin Repeat Containing (BTRC) antibodyBTRC 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated
anti-beta-Transducin Repeat Containing (BTRC) (AA 52-354) antibodyBTRC 适用: 人 WB, FACS 宿主: 小鼠 Monoclonal 1F10 unconjugated
anti-beta-Transducin Repeat Containing (BTRC) (AA 24-60), (N-Term) antibodyBTRC 适用: 人 WB, IF, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
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说明
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Validation: Orthogonal
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal
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储存液
- Thimerosal (Merthiolate)
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注意事项
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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: "REST reduction is essential for hypoxia-induced neuroendocrine differentiation of prostate cancer cells by activating autophagy signaling." in: Oncotarget, Vol. 7, Issue 18, pp. 26137-51, (2018) (PubMed).
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: "REST reduction is essential for hypoxia-induced neuroendocrine differentiation of prostate cancer cells by activating autophagy signaling." in: Oncotarget, Vol. 7, Issue 18, pp. 26137-51, (2018) (PubMed).
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- BTRC (beta-Transducin Repeat Containing (BTRC))
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别名
- beta-transducin repeat containing E3 ubiquitin protein ligase
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背景
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This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class, in addition to an F-box, this protein contains multiple WD-40 repeats. This protein is homologous to Xenopus bTrCP1, yeast Met30, Neurospora Scon2 and Drosophila Slimb proteins. It interacts with HIV-1 Vpu and connects CD4 to the proteolytic machinery. It also associates specifically with phosphorylated IkappaBalpha and beta-catenin destruction motifs, probably functioning in multiple transcriptional programs by activating the NF-kappaB pathway and inhibiting the beta-catenin pathway.
Cellular Localization: Cytoplasm -
分子量
- 69 kDa
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基因ID
- 8945
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UniProt
- Q9Y297
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途径
- Cell Division Cycle, Hedgehog Signaling
抗原
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