BID 抗体
Quick Overview for BID 抗体 (ABIN2855009)
抗原
See all BID 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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特异性
- IP/MS validation was supported by references (PMID:30377376)
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交叉反应
- 人
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产品特性
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Rabbit polyclonal antibody to Bid (BH3 interacting domain death agonist)
Bid antibody [N1C3] -
纯化方法
- Purified by antigen-affinity chromatography.
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免疫原
- Recombinant protein encompassing a sequence within the center region of human Bid. The exact sequence is proprietary.
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亚型
- IgG
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应用备注
- WB: 1:1000-1:10000. IP: 1:100-1:500. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
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说明
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Positive Control: A431 , 293T
Validation: IP/MS, KO/KD
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.8 mg/mL
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缓冲液
- 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal
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储存液
- Thimerosal (Merthiolate)
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注意事项
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- BID (BH3 Interacting Domain Death Agonist (BID))
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别名
- BH3 interacting domain death agonist
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背景
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This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8), CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined.
Cellular Localization: Cytoplasm , Mitochondrion membrane , BH3-interacting domain death agonist p15: Mitochondrion membrane , BH3-interacting domain death agonist p13: Mitochondrion membrane , Isoform 1: Cytoplasm , Isoform 3: Cytoplasm , Isoform 2: Mitochondrion membrane -
分子量
- 22 kDa
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基因ID
- 637
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UniProt
- P55957
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途径
- Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity
抗原
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