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14-3-3 sigma/SFN 抗体

This anti-14-3-3 sigma/SFN antibody is a 兔 多克隆 antibody detecting 14-3-3 sigma/SFN in WB, IF, IP, IHC (p) 和 ICC. Suitable for 人. This Primary Antibody has been cited in 1 publication.
产品编号 ABIN2854867
发货至: 中国

Quick Overview for 14-3-3 sigma/SFN 抗体 (ABIN2854867)

抗原

See all 14-3-3 sigma/SFN (SFN) 抗体
14-3-3 sigma/SFN (SFN) (Stratifin (SFN))

适用

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宿主

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克隆类型

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多克隆

标记

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This 14-3-3 sigma/SFN antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)
  • 交叉反应

    人, 小鼠

    产品特性

    Rabbit Polyclonal antibody to 14-3-3 sigma (stratifin)
    14-3-3 sigma antibody

    纯化方法

    Purified by antigen-affinity chromatography.

    免疫原

    Recombinant protein encompassing a sequence within the center region of human 14-3-3 sigma. The exact sequence is proprietary.

    亚型

    IgG
  • 应用备注

    WB: 1:500-1:10000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

    说明

    Positive Control: A549 , 293T , A431 , HeLa , HepG2 , A375 , Neuro2A , GL261 , C8D30

    Validation: Orthogonal

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.32 mg/mL

    缓冲液

    0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

    储存液

    Thimerosal (Merthiolate)

    注意事项

    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Kim, Morales, Baek, Slaga, DiGiovanni, Kim: "UVB-induced nuclear translocation of TC-PTP by AKT/14-3-3σ axis inhibits keratinocyte survival and proliferation." in: Oncotarget, Vol. 8, Issue 53, pp. 90674-90692, (2017) (PubMed).

  • 抗原

    14-3-3 sigma/SFN (SFN) (Stratifin (SFN))

    别名

    stratifin

    背景

    Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. p53-regulated inhibitor of G2/M progression.

    Cellular Localization: Cytoplasm , Nucleus , Secreted

    分子量

    28 kDa

    基因ID

    2810

    UniProt

    P31947

    途径

    p53 Pathway, Myometrial Relaxation and Contraction
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