Survivin 抗体
Quick Overview for Survivin 抗体 (ABIN2854750)
抗原
See all Survivin (BIRC5) 抗体适用
宿主
克隆类型
标记
应用范围
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交叉反应
- 人, 小鼠
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产品特性
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Rabbit Polyclonal antibody to Survivin (baculoviral IAP repeat containing 5)
Survivin antibody -
纯化方法
- Purified by antigen-affinity chromatography.
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免疫原
- Recombinant protein encompassing a sequence within the center region of human Survivin. The exact sequence is proprietary.
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亚型
- IgG
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anti-Baculoviral IAP Repeat-Containing 5 (BIRC5) (AA 85-142) antibody
BIRC5 适用: 人, 小鼠 WB, ELISA, IHC (p), FACS, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Baculoviral IAP Repeat-Containing 5 (BIRC5) (AA 1-100) antibodyBIRC5 适用: 人 WB, ELISA, IF, IP, RNAi 宿主: 小鼠 Monoclonal 5B10 unconjugated
anti-Baculoviral IAP Repeat-Containing 5 (BIRC5) (AA 1-142) antibodyBIRC5 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Baculoviral IAP Repeat-Containing 5 (BIRC5) (AA 1-142) antibodyBIRC5 适用: 人 WB, IHC, ICC, IP 宿主: 小鼠 Monoclonal C3 unconjugated
anti-Baculoviral IAP Repeat-Containing 5 (BIRC5) (pThr117) antibodyBIRC5 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Baculoviral IAP Repeat-Containing 5 (BIRC5) antibodyBIRC5 适用: 人 WB, ELISA, IHC, ICC, FACS 宿主: 小鼠 Monoclonal 1H5 unconjugated
anti-Baculoviral IAP Repeat-Containing 5 (BIRC5) (C-Term) antibodyBIRC5 适用: 人 WB, IF, ICC, IP, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Baculoviral IAP Repeat-Containing 5 (BIRC5) (AA 1-142) antibodyBIRC5 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Baculoviral IAP Repeat-Containing 5 (BIRC5) (AA 1-142) antibodyBIRC5 适用: 人 WB, IF, PLA 宿主: 兔 Polyclonal unconjugated
anti-Baculoviral IAP Repeat-Containing 5 (BIRC5) (AA 1-142) antibodyBIRC5 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
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说明
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Positive Control: 293T , NIH-3T3
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1XPBS ( pH 7), 40 % Glycerol, 0.01 % Thimerosal
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储存液
- Thimerosal (Merthiolate)
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注意事项
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- Survivin (BIRC5) (Baculoviral IAP Repeat-Containing 5 (BIRC5))
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别名
- baculoviral IAP repeat containing 5
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背景
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Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex, directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7. Isoform 2 and isoform 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform.
Cellular Localization: Cytoplasm , Nucleus , Centromere -
分子量
- 16 kDa
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基因ID
- 332
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UniProt
- O15392
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途径
- Apoptosis, Cell Division Cycle, Nuclear Hormone Receptor Binding
抗原
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