DDB1 抗体 (C-Term)
Quick Overview for DDB1 抗体 (C-Term) (ABIN2854664)
抗原
See all DDB1 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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                                            抗原表位
- C-Term
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                                            交叉反应
- 人, 小鼠, 大鼠
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                                            产品特性
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                        Rabbit Polyclonal antibody to DDB1 (damage-specific DNA binding protein 1, 127 kDa)
 DDB1 antibody [C3], C-term
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                                            纯化方法
- Purified by antigen-affinity chromatography.
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                                            免疫原
- Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human DDB1. The exact sequence is proprietary.
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                                            亚型
- IgG
 
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                                            应用备注
- WB: 1:500-1:10000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
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                                            说明
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                        Positive Control: A549 , H1299 , HCT116 , MCF-7 , Neuro2A , GL261 , C8D30 , PC-12 , 293T Validation: KO/KD 
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                                            限制
- 仅限研究用
 
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                                            状态
- Liquid
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                                            浓度
- 1 mg/mL
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                                            缓冲液
- 1XPBS ( pH 7), 20 % Glycerol, 0.01 % Thimerosal
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                                            储存液
- Thimerosal (Merthiolate)
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                                            注意事项
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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                                            储存条件
- 4 °C,-20 °C
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                                            储存方法
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
 
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                                            : "Comparative Interactome Analysis of Emerin, MAN1 and LEM2 Reveals a Unique Role for LEM2 in Nucleotide Excision Repair."    in: Cells, Vol. 9, Issue 2, (2020)         (PubMed).        
 
 
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                                            : "Comparative Interactome Analysis of Emerin, MAN1 and LEM2 Reveals a Unique Role for LEM2 in Nucleotide Excision Repair."    in: Cells, Vol. 9, Issue 2, (2020)         (PubMed).        
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    - DDB1 (Damage Specific DNA Binding Protein 1 (DDB1))
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                                            别名
- damage specific DNA binding protein 1
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                                            背景
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                        This gene encodes the large subunit of DNA damage-binding protein which is a heterodimer composed of a large and a small subunit. This protein functions in nucleotide-excision repair. Its defective activity causes the repair defect in the patients with xeroderma pigmentosum complementation group E (XPE). However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. 
 Cellular Localization: Cytoplasm , Nucleus
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                                            分子量
- 127 kDa
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                                            基因ID
- 1642
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                                            UniProt
- Q16531
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                                            途径
- DNA Damage Repair
 抗原
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