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DDB1 抗体 (C-Term)

This anti-DDB1 antibody is a 兔 多克隆 antibody detecting DDB1 in WB, IF, IHC (p) 和 ICC. Suitable for 人. This Primary Antibody has been cited in 1 publication.
产品编号 ABIN2854664
发货至: 中国

Quick Overview for DDB1 抗体 (C-Term) (ABIN2854664)

抗原

See all DDB1 抗体
DDB1 (Damage Specific DNA Binding Protein 1 (DDB1))

适用

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宿主

  • 37
  • 7
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克隆类型

  • 35
  • 10
多克隆

标记

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This DDB1 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

质量等级

KO Validated
  • 抗原表位

    • 7
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    C-Term

    交叉反应

    人, 小鼠, 大鼠

    产品特性

    Rabbit Polyclonal antibody to DDB1 (damage-specific DNA binding protein 1, 127 kDa)
    DDB1 antibody [C3], C-term

    纯化方法

    Purified by antigen-affinity chromatography.

    免疫原

    Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human DDB1. The exact sequence is proprietary.

    亚型

    IgG
  • 应用备注

    WB: 1:500-1:10000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

    说明

    Positive Control: A549 , H1299 , HCT116 , MCF-7 , Neuro2A , GL261 , C8D30 , PC-12 , 293T

    Validation: KO/KD

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    1XPBS ( pH 7), 20 % Glycerol, 0.01 % Thimerosal

    储存液

    Thimerosal (Merthiolate)

    注意事项

    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Moser, Basílio, Gotzmann, Brachner, Foisner: "Comparative Interactome Analysis of Emerin, MAN1 and LEM2 Reveals a Unique Role for LEM2 in Nucleotide Excision Repair." in: Cells, Vol. 9, Issue 2, (2020) (PubMed).

  • 抗原

    DDB1 (Damage Specific DNA Binding Protein 1 (DDB1))

    别名

    damage specific DNA binding protein 1

    背景

    This gene encodes the large subunit of DNA damage-binding protein which is a heterodimer composed of a large and a small subunit. This protein functions in nucleotide-excision repair. Its defective activity causes the repair defect in the patients with xeroderma pigmentosum complementation group E (XPE). However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients.

    Cellular Localization: Cytoplasm , Nucleus

    分子量

    127 kDa

    基因ID

    1642

    UniProt

    Q16531

    途径

    DNA Damage Repair
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