NOTCH3 抗体 (C-Term)
Quick Overview for NOTCH3 抗体 (C-Term) (ABIN2854480)
抗原
See all NOTCH3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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交叉反应
- 小鼠, 大鼠
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交叉反应 (详细)
- Mouse (100 %), Rat (100 %)
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产品特性
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Rabbit polyclonal antibody to Notch 3 (Notch homolog 3 (Drosophila))
Notch 3 antibody [C3], C-term -
纯化方法
- Affinity purified by Protein A.
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免疫原
- Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human Notch 3. The exact sequence is proprietary.
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亚型
- IgG
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应用备注
- Suggested dilution Reference Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceWestern blot1:500-1:3000*
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说明
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Positive Control: HeLa
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 5.26 mg/mL
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缓冲液
- 0.1M Tris, 0.1M Glycine, 10 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.
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储存液
- Thimerosal (Merthiolate)
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注意事项
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- NOTCH3 (Notch 3 (NOTCH3))
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别名
- Notch 3
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背景
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This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
Cellular Localization: Cell membrane, Single-pass type I membrane protein , Notch 3 intracellular domain: Nucleus -
分子量
- 244 kDa
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基因ID
- 4854
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途径
- Notch Signaling
抗原
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