SUMO4 抗体 (Val55-Mutant)
Quick Overview for SUMO4 抗体 (Val55-Mutant) (ABIN2797851)
抗原
See all SUMO4 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- Val55-Mutant
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原理
- Rabbit Anti-Human SUMO4 (V55 Mutant) Antibody
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免疫原
- This SUMO4 antibody is generated from rabbits immunized with a KLH conjugated peptide CEPRGLS(V)KQIRFRFG selected from human SUMO4. This antibody is affinity purified using peptides CEPRGLS(V)KQIRFRFG (positive selection) and CEPRGLS(M)KQIRFRFG (negative selection).
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亚型
- Ig Fraction
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anti-Small Ubiquitin Related Modifier 4 (SUMO4) antibody
SUMO4 适用: 人 WB, IHC, IF 宿主: 兔 Monoclonal unconjugated
anti-Small Ubiquitin Related Modifier 4 (SUMO4) (Mutant), (Val55) antibodySUMO4 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB7264 unconjugated
anti-Small Ubiquitin Related Modifier 4 (SUMO4) antibodySUMO4 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Small Ubiquitin Related Modifier 4 (SUMO4) (AA 1-95) antibodySUMO4 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Small Ubiquitin Related Modifier 4 (SUMO4) (AA 1-95) antibodySUMO4 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1D3 unconjugated
anti-Small Ubiquitin Related Modifier 4 (SUMO4) (AA 34-63) antibodySUMO4 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB7262 unconjugated
anti-Small Ubiquitin Related Modifier 4 (SUMO4) antibodySUMO4 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Small Ubiquitin Related Modifier 4 (SUMO4) (AA 34-63), (Wild Type) antibodySUMO4 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Small Ubiquitin Related Modifier 4 (SUMO4) (M55V) antibodySUMO4 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Small Ubiquitin Related Modifier 4 (SUMO4) (M55V) antibodySUMO4 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western Blot, Immunohistochemistry
Recommended Dilutions
WB: 1:1000, IHC: 1:50-100Western blot analysis of SUMO4 Antibody (V55 Mutant) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry, clinical relevance has not been evaluated.
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry, clinical relevance has not been evaluated. BC = breast carcinoma, HC = hepatocarcinoma. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 2.0 mg/mL
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储存条件
- 4 °C,-20 °C
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储存方法
- 2-8°C (short-term), -20°C (long-term)
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- SUMO4 (Small Ubiquitin Related Modifier 4 (SUMO4))
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别名
- SUMO4
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背景
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Target Description: SUMO4 is a member of the SUMO gene family. This family of small ubiquitin-related modifiers covalently modify target lysines in proteins and control the target proteins' subcellular localization, stability, or activity. Upon oxidative stress, SUMO4 conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. This protein may also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to SUMO4 substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I. In contrast to SUMO1, SUMO2 and SUMO3, SUMO4 seems to be insensitive to sentrin-specific proteases due to the presence of Pro-90. This may impair processing to mature form and conjugation to substrates. SUMO4 is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. The M55V substitution has been associated with type I diabetes.
Gene Symbol: SUMO4
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分子量
- 10685 Da
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基因ID
- 387082
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UniProt
- Q6EEV6
抗原
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