SSRP1 抗体 (Middle Region)
Quick Overview for SSRP1 抗体 (Middle Region) (ABIN2792588)
抗原
See all SSRP1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Middle Region
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序列
- MKEYEGGRGE SSKRDKSKKK KKVKVKMEKK STPSRGSSSK SSSRQLSESF
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交叉反应
- 牛, Fruit Fly (Drosophila melanogaster), 人, 小鼠, 大鼠
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预测反应
- Cow: 100%, Human: 100%, Mouse: 100%, Rat: 100%
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产品特性
- This is a rabbit polyclonal antibody against SSRP1. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the middle region of human SSRP1
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anti-Structure Specific Recognition Protein 1 (SSRP1) antibody
SSRP1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Structure Specific Recognition Protein 1 (SSRP1) antibodySSRP1 适用: 人, 小鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Structure Specific Recognition Protein 1 (SSRP1) (AA 1-300) antibodySSRP1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Structure Specific Recognition Protein 1 (SSRP1) (AA 1-242) antibodySSRP1 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Structure Specific Recognition Protein 1 (SSRP1) antibodyKO Validated SSRP1 适用: 人 WB, IP, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Structure Specific Recognition Protein 1 (SSRP1) antibodySSRP1 适用: 人, 小鼠, 大鼠 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Structure Specific Recognition Protein 1 (SSRP1) (N-Term) antibodySSRP1 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马 WB 宿主: 兔 Polyclonal unconjugated
anti-Structure Specific Recognition Protein 1 (SSRP1) antibodySSRP1 适用: 人 WB 宿主: 小鼠 Monoclonal 10D7 unconjugated
anti-Structure Specific Recognition Protein 1 (SSRP1) antibodySSRP1 适用: 人 WB 宿主: 小鼠 Monoclonal 3E4 unconjugated
anti-Structure Specific Recognition Protein 1 (SSRP1) (AA 611-660) antibodySSRP1 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, Pig, 猴, Bat, Drosophila melanogaster, Hamster WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB Suggested Anti-SSRP1 Antibody Titration: 0.2-1 µg/mL
ELISA Titer: 1:312500
Positive Control: Human Spleen.
Optimal working dilutions should be determined experimentally by the investigator. -
说明
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Antigen size: 709 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- SSRP1 (Structure Specific Recognition Protein 1 (SSRP1))
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别名
- SSRP1 / FACT80
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背景
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SSRP1 is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. SSRP1 contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. It also functions as a co-activator of the transcriptional activator p63. The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: FACT, FACT80, T160
Protein Interaction Partner: SUMO2, SUMO3, ATRX, UBC, EED, RNF2, SEC24C, CUL1, CSDE1, ATP6V1B2, DIABLO, SBNO1, PBDC1, EXOSC10, CSNK2A1, PNKP, VCAM1, SRPK1, ITGA4, FMNL1, SUPT16H, CENPA, LEO1, PAF1, PHGDH, SF3B1, NCSTN, RTF1, RBM14, SAP18, CTR9, S100A9, NOP2, HMGB1, HIST1H2BB, DHX9, C
Protein Size: 709 -
分子量
- 81 kDa
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基因ID
- 6749
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NCBI登录号
- NM_003146, NP_003137
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UniProt
- Q08945
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途径
- Chromatin Binding
抗原
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