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FADD 抗体 (C-Term)

Name: FADD 抗体 (C-Term)
SKU: ABIN2792110
Availability: OutOfStock

This anti-FADD antibody is a 兔多克隆 antibody detecting FADD in WB 和 IHC. Suitable for 人. This Primary Antibody has been cited in 1 publication.

WB Suggested Anti-FADD Antibody Titration: 0. (FADD 抗体 (C-Term))

IHC

2 images

(1 reference)

产品编号 ABIN2792110

发货至: 中国

Quick Overview for FADD 抗体 (C-Term) (ABIN2792110)

抗原

See all FADD 抗体

FADD (Fas (TNFRSF6)-Associated Via Death Domain (FADD))

适用

人

宿主

兔

克隆类型

多克隆

标记

This FADD antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (IHC)

Discover our top product FADD Primary Antibody

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C-Term

序列

AHLVGALRSC QMNLVADLVQ EVQQARDLQN RSGAMSPMSW NSDASTSEAS

预测反应

Human: 100%

产品特性

This is a rabbit polyclonal antibody against FADD. It was validated on Western Blot and immunohistochemistry.

纯化方法

Affinity Purified

免疫原

The immunogen is a synthetic peptide directed towards the C terminal region of human FADD
anti-Fas (TNFRSF6)-Associated Via Death Domain (FADD) (AA 12-206) antibody
FADD 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Fas (TNFRSF6)-Associated Via Death Domain (FADD) (AA 1-208) antibody
FADD 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated

anti-Fas (TNFRSF6)-Associated Via Death Domain (FADD) (AA 20-150) antibody
FADD 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 5A6A2 unconjugated

anti-Fas (TNFRSF6)-Associated Via Death Domain (FADD) (AA 7-178) antibody
FADD 适用: 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Fas (TNFRSF6)-Associated Via Death Domain (FADD) (AA 1-208) antibody
FADD 适用: 人 WB, IHC, ELISA, IF, ICC 宿主: 小鼠 Monoclonal J1D2 unconjugated

anti-Fas (TNFRSF6)-Associated Via Death Domain (FADD) (AA 1-208) antibody
FADD 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated

anti-Fas (TNFRSF6)-Associated Via Death Domain (FADD) (AA 109-208) antibody
FADD 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3C3 unconjugated

anti-Fas (TNFRSF6)-Associated Via Death Domain (FADD) antibody
FADD 适用: 小鼠 WB, IHC 宿主: 兔 Monoclonal unconjugated

anti-Fas (TNFRSF6)-Associated Via Death Domain (FADD) (AA 1-80) antibody
FADD 适用: 人, 小鼠, 大鼠, 猴, Pig WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Fas (TNFRSF6)-Associated Via Death Domain (FADD) (pSer191) antibody
FADD 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

应用备注

Optimal working dilutions should be determined experimentally by the investigator.

说明

Antigen size: 208 AA

限制

仅限研究用
状态

Liquid

浓度

Lot specific

缓冲液

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freeze-thaw cycles.

储存条件

-20 °C

储存方法

For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Thomas, Henson, Reed, Salsbury, Thorburn: "Direct binding of Fas-associated death domain (FADD) to the tumor necrosis factor-related apoptosis-inducing ligand receptor DR5 is regulated by the death effector domain of FADD." in: The Journal of biological chemistry, Vol. 279, Issue 31, pp. 32780-5, (2004) (PubMed).
抗原

FADD (Fas (TNFRSF6)-Associated Via Death Domain (FADD))

别名

FADD

背景

The protein encoded by FADD is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade.
Alias Symbols: GIG3, MORT1
Protein Interaction Partner: CFLAR, CASP10, CASP8, ATG5, ATG12, TNF, TRADD, UBC, RIPK1, FAS, TNFSF10, SPOP, TNFRSF1A, MYD88, TNFRSF10A, TNFRSF10B, MKRN1, RIPK3, CUL3, TRAF2, PARK7, FASLG, LRRK2, IKBKG, BMX, FAF1, EDAR, DAPK1, CLIP3, DAXX, TNFAIP3, MAVS, KHDRBS1, TAB1, EZR, TRIM21, IR
Protein Size: 208

分子量

23 kDa

基因ID

8772

NCBI登录号

NM_003824, NP_003815

UniProt

Q13158

途径

Apoptosis, TLR signaling, Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades