Caspase 10 抗体 (Middle Region)
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Quick Overview for Caspase 10 抗体 (Middle Region) (ABIN567450)
抗原
See all Caspase 10 (CASP10) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Middle Region
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序列
- HNNVTKVEME MVLQKQKCNP AHADGDCFVF CILTHGRFGA VYSSDEALIP
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预测反应
- Human: 100%
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产品特性
- This is a rabbit polyclonal antibody against CASP10. It was validated on Western Blot.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the middle region of human CASP10
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 479 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Caspase 10 (CASP10) (Caspase 10, Apoptosis-Related Cysteine Peptidase (CASP10))
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别名
- CASP10
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背景
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This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with apoptosis defects seen in type II autoimmune lymphoproliferative syndrome. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Alias Symbols: ALPS2, FLICE2, MCH4
Protein Interaction Partner: FADD, PRDX6, XIAP, RB1, Dlg4, PHF20L1, OIP5, ECE2, RIOK3, NFKBIL1, CASP8, RNF34, BFAR, CASP8AP2, MSN2, PTC2, AIM9, GLN3, SLT2, GPA1, STE20, ATG13, RPL21B, VPS30, CUP9, TPK2, GAL4, FAR11, WHI3, ATG4, FAR3, FAR8, ITT1, MPH1, SSM4, ASG1, BFR1, ORT1, MBR1, CW
Protein Size: 479 -
分子量
- 12 kDa
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基因ID
- 843
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NCBI登录号
- NM_001230, NP_001221
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UniProt
- Q92851
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途径
- Apoptosis, Caspase Cascade in Apoptosis
抗原
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