Presenilin 1 抗体 (Middle Region)
Quick Overview for Presenilin 1 抗体 (Middle Region) (ABIN2787886)
抗原
See all Presenilin 1 (PSEN1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Middle Region
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序列
- EGDPEAQRRV SKNSKYNAES TERESQDTVA ENDDGGFSEE WEAQRDSHLG
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预测反应
- Cow: 86%, Dog: 86%, Guinea Pig: 100%, Horse: 86%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 85%
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产品特性
- This is a rabbit polyclonal antibody against PSEN1. It was validated on Western Blot.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the middle region of human PSEN1
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anti-Presenilin 1 (PSEN1) (AA 1-160) antibody
PSEN1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Presenilin 1 (PSEN1) (AA 330-359), (C-Term) antibodyPSEN1 适用: 人, 小鼠 WB, IHC (p), IF, FACS 宿主: 兔 Polyclonal RB2257 unconjugated
anti-Presenilin 1 (PSEN1) (AA 4-218) antibodyPSEN1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Presenilin 1 (PSEN1) (AA 1-160) antibodyPSEN1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Presenilin 1 (PSEN1) (AA 300-349) antibodyPSEN1 适用: 人, 小鼠, 猴, Cow, Pig, 豚鼠, 马 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Presenilin 1 (PSEN1) (AA 107-156) antibodyPSEN1 适用: 人, 小鼠, 大鼠, 猴, Pig, 豚鼠, 犬, Bat, Hamster WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Presenilin 1 (PSEN1) (N-Term) antibodyPSEN1 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 犬, 马, 兔, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Presenilin 1 (PSEN1) (AA 10-80) antibodyPSEN1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), FACS, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Presenilin 1 (PSEN1) (AA 299-350) antibodyPSEN1 适用: 人 WB, ELISA, IF (cc), IF (p), IHC (fro) 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 467 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Presenilin 1 (PSEN1)
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别名
- PSEN1
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背景
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Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1, PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.
Alias Symbols: AD3, FAD, PS1, S182, PS-1
Protein Interaction Partner: UBC, TRAF6, TGFBR1, ERLIN2, PSMB1, PSMA5, ETFA, TDP2, PSEN2, PSEN1, APH1B, PSENEN, APH1A, NCSTN, ITSN2, PDCD4, KANK2, EPB41L3, CDC37, TUBA1B, AP1M2, UMPS, PRDX2, ST13, SCN1A, RHEB, RAD23A, RAB3A, OXCT1, NOS3, NDUFS8, HMGB1, GCDH, GAPDH, FGF13, ENSA, DTNA,
Protein Size: 467 -
分子量
- 53 kDa
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基因ID
- 5663
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NCBI登录号
- NM_000021, NP_000012
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UniProt
- P49768
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途径
- Notch Signaling, EGFR Signaling Pathway, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport
抗原
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