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Gelsolin 抗体 (C-Term)

This 兔多克隆 antibody specifically detects Gelsolin in WB 和 IHC. It exhibits reactivity toward 人, 小鼠, 大鼠, Cow, 兔, 犬, 马, 绵羊, 斑马鱼和豚鼠.It has been mentioned in 1 publication

IHC

1 image

(1 reference)

产品编号 ABIN2785642

发货至: 中国

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Quick Overview for Gelsolin 抗体 (C-Term) (ABIN2785642)

抗原

See all Gelsolin (GSN) 抗体

Gelsolin (GSN)

适用

人, 小鼠, 大鼠, Cow, 兔, 犬, 马, 绵羊, 斑马鱼, 豚鼠

宿主

兔

克隆类型

多克隆

标记

This Gelsolin antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (IHC)

Discover our top product GSN Primary Antibody

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C-Term

序列

KPMIIYKGGT SREGGQTAPA STRLFQVRAN SAGATRAVEV LPKAGALNSN

预测反应

Cow: 100%, Dog: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 100%, Sheep: 100%, Zebrafish: 100%

产品特性

This is a rabbit polyclonal antibody against GSN. It was validated on Western Blot using a cell lysate as a positive control.

纯化方法

Affinity Purified

免疫原

The immunogen is a synthetic peptide directed towards the C terminal region of human GSN
anti-Gelsolin (GSN) (AA 170-423) antibody
GSN 适用: Cow WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C2 unconjugated

anti-Gelsolin (GSN) (AA 577-771) antibody
GSN 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Gelsolin (GSN) (AA 674-782) antibody
GSN 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Gelsolin (GSN) (AA 543-782) antibody
GSN 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Gelsolin (GSN) (AA 673-782) antibody
GSN 适用: 人 WB, IP, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 3G5 unconjugated

anti-Gelsolin (GSN) antibody
GSN 适用: 人 IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 5E3B9 unconjugated

anti-Gelsolin (GSN) (AA 432-553) antibody
GSN 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C1 unconjugated

anti-Gelsolin (GSN) (AA 432-625) antibody
GSN 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Gelsolin (GSN) (AA 1-782) antibody
GSN 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated

anti-Gelsolin (GSN) (C-Term) antibody
KO Validated GSN 适用: 人 WB, ICC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated

应用备注

Optimal working dilutions should be determined experimentally by the investigator.

说明

Antigen size: 782 AA

限制

仅限研究用
状态

Liquid

浓度

Lot specific

缓冲液

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freeze-thaw cycles.

储存条件

-20 °C

储存方法

For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Shokouhi, Khosroshahi: "Ardalan-Shoja-Kiuru syndrome--hereditary gelsolin amyloidosis plus retinitis pigmentosa." in: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, Vol. 23, Issue 3, pp. 1071; author reply 1071-2, (2008) (PubMed).
抗原

Gelsolin (GSN)

别名

GSN

背景

GSN binds to the 'plus' ends of actin monomers and filaments to prevent monomer exchange. It is a calcium-regulated protein, which functions in both assembly and disassembly of actin filaments. Defects in the gene encoding GSN are a cause of familial amyloidosis Finnish type (FAF).The protein encoded by this gene binds to the 'plus' ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene.
Alias Symbols: DKFZp313L0718, ADF, AGEL
Protein Interaction Partner: ITCH, CFLAR, TP53, UBC, CASP3, UBD, FN1, MPG, ESR1, ALB, SDHB, ACTA1, MDM2, UBE2Q2, FBXO25, ARRB2, ARRB1, AR, PSMD4, TNIK, CLIC5, TOM1L1, ACTN4, VDAC1, BCAR1, PXN, LIMK2, VASP, PIK3CG, PTK2B, FHIT, VCL, CSK, APP, ACTB, ACTG1, PLCG1, SRC, PTPN12, PTK2, PIK
Protein Size: 782

分子量

83 kDa

基因ID

2934

NCBI登录号

NM_000177, NP_000168

UniProt

P06396

途径

Caspase Cascade in Apoptosis, Regulation of Actin Filament Polymerization, Autophagy