CISH 抗体 (N-Term)
Quick Overview for CISH 抗体 (N-Term) (ABIN2785100)
抗原
See all CISH 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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序列
- RESGWYWGSI TASEARQHLQ KMPEGTFLVR DSTHPSYLFT LSVKTTRGPT
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预测反应
- Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%
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产品特性
- This is a rabbit polyclonal antibody against Cish. It was validated on Western Blot.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide corresponding to a region of Mouse
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anti-Cytokine Inducible SH2-Containing Protein (CISH) (C-Term) antibody
CISH 适用: 人 WB, ICC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cytokine Inducible SH2-Containing Protein (CISH) (AA 1-258) antibodyCISH 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Cytokine Inducible SH2-Containing Protein (CISH) (AA 1-258) antibodyCISH 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Cytokine Inducible SH2-Containing Protein (CISH) (AA 1-258) antibodyCISH 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cytokine Inducible SH2-Containing Protein (CISH) (AA 79-256) antibodyCISH 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cytokine Inducible SH2-Containing Protein (CISH) (AA 1-257) antibodyCISH 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Cytokine Inducible SH2-Containing Protein (CISH) (AA 17-130) antibodyCISH 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Cytokine Inducible SH2-Containing Protein (CISH) (AA 241-258), (C-Term) antibodyCISH 适用: 人, 小鼠, 大鼠 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cytokine Inducible SH2-Containing Protein (CISH) (AA 241-258) antibodyCISH 适用: 人, 小鼠, 大鼠 WB, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cytokine Inducible SH2-Containing Protein (CISH) (AA 78-127) antibodyCISH 适用: 人, 小鼠, 大鼠, Pig, Cow, 马, 兔, 犬, Bat, 猴 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 257 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- CISH (Cytokine Inducible SH2-Containing Protein (CISH))
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别名
- Cish
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背景
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SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Alias Symbols: AI385595, CIS1, Cis, F17, F23
Protein Interaction Partner: GHR, Socs2, Lepr, Epor, Prkcq, Prkcb, Prkca, Ubc, Abl1, Cul5, TCEB2, TCEB1, Stat5a,
Protein Size: 257 -
分子量
- 28 kDa
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基因ID
- 12700
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NCBI登录号
- NM_009895, NP_034025
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UniProt
- Q62225
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途径
- JAK/STAT Signaling, Response to Growth Hormone Stimulus
抗原
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