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FBXW7 抗体 (C-Term)

Name: FBXW7 抗体 (C-Term)
SKU: ABIN2782955
Availability: OutOfStock

Cited in 1 publication. This 兔多克隆 anti-FBXW7 antibody specifically detects FBXW7 in WB 和 IHC. The antibody is reactive with 人, 小鼠, 大鼠, 犬, Cow, 兔, 豚鼠, 马和斑马鱼 samples.

Host: Rabbit Target Name: GNAS Sample Type: Human Fetal Heart Antibody Dilution: 1. (FBXW7 抗体 (C-Term))

Immunohistochemistry (IHC) image for anti-F-Box and WD Repeat Domain Containing 7 (FBXW7) (C-Term) antibody (ABIN2782955) (FBXW7 抗体 (C-Term))

IHC

WB Suggested Anti-FBXW7 Antibody Titration: 0. (FBXW7 抗体 (C-Term))

Host: Rabbit Target Name: FBXW7 Sample Type: 721_B Whole Cell lysates Antibody Dilution: 1. (FBXW7 抗体 (C-Term))

Host: Rabbit Target Name: FBXW7 Sample Type: 721_B Whole Cell lysates Antibody Dilution: 1ug/ml (FBXW7 抗体 (C-Term))

Rabbit Anti-FBXW7 Antibody Formalin Fixed Paraffin Embedded Tissue: Human Pineal Tissue Observed Staining: Cytoplasmic in cell bodies and processes of pinealocytes Primary Antibody Concentration: 1:100 Other Working Concentrations: 1/600 Secondary Antibody: Donkey anti-Rabbit-Cy3 Secondary Antibody Concentration: 1:200 Magnification: 20X Exposure Time: 0. (FBXW7 抗体 (C-Term))

IHC

7 images

(1 reference)

产品编号 ABIN2782955

发货至: 中国

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Quick Overview for FBXW7 抗体 (C-Term) (ABIN2782955)

抗原

See all FBXW7 抗体

FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))

适用

人, 小鼠, 大鼠, 犬, Cow, 兔, 豚鼠, 马, 斑马鱼

宿主

兔

克隆类型

多克隆

标记

This FBXW7 antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (IHC)

抗原表位
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C-Term

序列

LKTGEFIRNL VTLESGGSGG VVWRIRASNT KLVCAVGSRN GTEETKLLVL

预测反应

Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

产品特性

This is a rabbit polyclonal antibody against FBXW7. It was validated on Western Blot.

纯化方法

Affinity Purified

免疫原

The immunogen is a synthetic peptide directed towards the C-terminal region of Human FBXW7
anti-F-Box and WD Repeat Domain Containing 7 (FBXW7) (AA 501-600) antibody
FBXW7 适用: 人, 小鼠, 大鼠 WB, ELISA, IF (p), IHC (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-F-Box and WD Repeat Domain Containing 7 (FBXW7) (AA 599-707) antibody
FBXW7 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 3D1 unconjugated

anti-F-Box and WD Repeat Domain Containing 7 (FBXW7) (AA 1-627) antibody
FBXW7 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated

anti-F-Box and WD Repeat Domain Containing 7 (FBXW7) (AA 279-515) antibody
FBXW7 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-F-Box and WD Repeat Domain Containing 7 (FBXW7) (AA 1-707) antibody
FBXW7 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-F-Box and WD Repeat Domain Containing 7 (FBXW7) (AA 599-707) antibody
FBXW7 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated

anti-F-Box and WD Repeat Domain Containing 7 (FBXW7) (AA 599-708) antibody
FBXW7 适用: 人 WB, IHC, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 3D1 unconjugated

anti-F-Box and WD Repeat Domain Containing 7 (FBXW7) (C-Term) antibody
FBXW7 适用: 人, 小鼠, 大鼠, 犬, Cow, Pig, 兔, 豚鼠, 马, 斑马鱼, Drosophila melanogaster, 猴, 非洲爪蟾, Hamster, Bat, 小鸡 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-F-Box and WD Repeat Domain Containing 7 (FBXW7) (AA 251-300) antibody
FBXW7 适用: 小鼠, 大鼠, Hamster WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-F-Box and WD Repeat Domain Containing 7 (FBXW7) (AA 177-208), (N-Term) antibody
FBXW7 适用: 人 WB 宿主: 兔 Polyclonal RB51853 unconjugated

应用备注

Optimal working dilutions should be determined experimentally by the investigator.

说明

Antigen size: 589 AA

限制

仅限研究用
状态

Liquid

浓度

Lot specific

缓冲液

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freeze-thaw cycles.

储存条件

-20 °C

储存方法

For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Gong, Zack, Morris, Lin, Hukkelhoven, Raheja, Tan, Turcan, Veeriah, Meng, Viale, Schumacher, Palmedo, Beroukhim, Chan: "Pan-cancer genetic analysis identifies PARK2 as a master regulator of G1/S cyclins." in: Nature genetics, Vol. 46, Issue 6, pp. 588-94, (2014) (PubMed).
抗原

FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))

别名

FBXW7

背景

FBXW7 is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in FBXW7 gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers.
Alias Symbols: AGO, CDC4, FBW6, FBW7, FBX30, FBXO30, FBXW6, SEL-10, SEL10, hAgo, hCdc4
Protein Interaction Partner: MCL1, CDC34, CCNE1, FBXW7, CUL1, UBE2D1, PIN1, DAB2IP, YAP1, SKP1, MAP4K1, EYA1, KLF5, SREBF1, NOTCH1, UBE2QL1, Creb3l2, Creb3l1, SIC1, CSF3R, KLF2, NCOA3, PTEN, NFE2L1, HSP90AA1, MED11, MED19, MED8, MED30, MED10, MED28, MED29, MED9, MED15, MED31, MED4, M
Protein Size: 707

分子量

80 kDa

基因ID

55294

NCBI登录号

NM_001013415, NP_001013433

途径

Notch Signaling, EGFR Signaling Pathway