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Nkx2-2 抗体 (N-Term)

This anti-Nkx2-2 antibody is a 兔 多克隆 antibody detecting Nkx2-2 in WB. Suitable for 人, 小鼠, 大鼠, Cow, 犬, 兔, 豚鼠, 马, 绵羊 和 斑马鱼. This Primary Antibody has been cited in 1 publication.
产品编号 ABIN2780436
发货至: 中国

Quick Overview for Nkx2-2 抗体 (N-Term) (ABIN2780436)

抗原

See all Nkx2-2 抗体
Nkx2-2 (NK2 Homeobox 2 (Nkx2-2))

适用

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人, 小鼠, 大鼠, Cow, 犬, 兔, 豚鼠, 马, 绵羊, 斑马鱼

宿主

  • 75
  • 61

克隆类型

  • 88
  • 48
多克隆

标记

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This Nkx2-2 antibody is un-conjugated

应用范围

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Western Blotting (WB)
  • 抗原表位

    • 39
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    N-Term

    序列

    MSLTNTKTGF SVKDILDLPD TNDEEGSVAE GPEEENEGPE PAKRAGPLGQ

    预测反应

    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 100%, Sheep: 100%, Zebrafish: 100%

    产品特性

    This is a rabbit polyclonal antibody against NKX2-2. It was validated on Western Blot using a cell lysate as a positive control.

    纯化方法

    Affinity Purified

    免疫原

    The immunogen is a synthetic peptide directed towards the N terminal region of human NKX2-2
  • 应用备注

    Optimal working dilutions should be determined experimentally by the investigator.

    说明

    Antigen size: 273 AA

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    Lot specific

    缓冲液

    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freeze-thaw cycles.

    储存条件

    -20 °C

    储存方法

    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Owen, Kowalewski, Lessnick: "EWS/FLI mediates transcriptional repression via NKX2.2 during oncogenic transformation in Ewing's sarcoma." in: PLoS ONE, Vol. 3, Issue 4, pp. e1965, (2008) (PubMed).

  • 抗原

    Nkx2-2 (NK2 Homeobox 2 (Nkx2-2))

    别名

    NKX2-2

    背景

    Nkx2-2 contains 1 homeobox DNA-binding domain which is essential for interaction with OLIG2. Nkx2-2 may be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. The protein encoded by this gene contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor.
    Alias Symbols: NKX2.2, NKX2B
    Protein Interaction Partner: Dlg4, SIN3A, HDAC1, OLIG2,
    Protein Size: 273

    分子量

    30 kDa

    基因ID

    4821

    NCBI登录号

    NM_002509, NP_002500

    UniProt

    O95096

    途径

    Dopaminergic Neurogenesis
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