ATF4 抗体 (C-Term)
Quick Overview for ATF4 抗体 (C-Term) (ABIN2780378)
抗原
See all ATF4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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序列
- EQNKTAATRY RQKKRAEQEA LTGECKELEK KNEALKERAD SLAKEIQYLK
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预测反应
- Cow: 93%, Dog: 100%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Rat: 93%, Sheep: 93%, Yeast: 82%
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产品特性
- This is a rabbit polyclonal antibody against ATF4. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
- Protein A purified
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免疫原
- The immunogen is a synthetic peptide directed towards the C terminal region of human ATF4
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 351 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- ATF4 (Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) (ATF4))
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别名
- ATF4
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背景
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ATF4s a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromsome at q28 in a region containing a large inverted duplication.
Alias Symbols: CREB2, TXREB, CREB-2, TAXREB67
Protein Interaction Partner: GPS2, GOLGA1, EP300, CEBPG, GOLGA8F, GOLGA8EP, GCC1, TRIB3, CCDC106, LDOC1, FBXW11, NDC80, BTRC, BFSP2, DDIT3, CREBBP, NEK6, JUN, FOS, ATF2, CEBPE, CEBPA, ATF4, ATF3, BATF2, CREBZF, BATF3, BATF, CREB3, MAFB, FOSL1, NFE2L2, NFE2, MAF, UBC, TGM2, RPS6, MAP2
Protein Size: 351 -
分子量
- 39 kDa
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基因ID
- 468
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NCBI登录号
- NM_001675, NP_001666
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UniProt
- P18848
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途径
- Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction, ER-Nucleus Signaling, Unfolded Protein Response
抗原
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