IRF5 抗体 (N-Term)
Quick Overview for IRF5 抗体 (N-Term) (ABIN2779987)
抗原
See all IRF5 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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序列
- CSNGPAPTES QPTDDYVLGE EEEEEEEELQ RMLPGLSITE PALPGPPNAP
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预测反应
- Mouse: 100%, Rat: 100%
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产品特性
- This is a rabbit polyclonal antibody against IRF5. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the N terminal region of mouse IRF5
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 497 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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: "Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors." in: Nature, Vol. 434, Issue 7030, pp. 243-9, (2005) (PubMed).
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: "Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors." in: Nature, Vol. 434, Issue 7030, pp. 243-9, (2005) (PubMed).
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- IRF5 (Interferon Regulatory Factor 5 (IRF5))
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别名
- IRF5
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背景
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The activation of Toll-like receptors (TLRs) is central to innate and adaptive immunity. All TLRs use the adaptor MyD88 for signaling. IRF-5 is generally involved downstream of the TLR-MyD88 signalling pathway for gene induction of proinflammatory cytokines, such as interleukin-6 (IL-6), IL-12 and tumour-necrosis factor-alpha.
Alias Symbols: mirf5, AW491843
Protein Interaction Partner: Ubc, Traf6, Irak1, Zfp764, Myd88, Il12b,
Protein Size: 497 -
分子量
- 55 kDa
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基因ID
- 27056
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NCBI登录号
- NM_012057, NP_036187
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UniProt
- P56477
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途径
- TLR signaling, Autophagy
抗原
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