EPAS1 抗体 (Middle Region)
Quick Overview for EPAS1 抗体 (Middle Region) (ABIN2779523)
抗原
See all EPAS1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Middle Region
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序列
- ESLFKPHLMA MNSIFDSSGK GAVSEKSNFL FTKLKEEPEE LAQLAPTPGD
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预测反应
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%
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产品特性
- This is a rabbit polyclonal antibody against EPAS1. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the middle region of human EPAS1
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anti-Endothelial PAS Domain Protein 1 (EPAS1) (AA 339-541) antibody
EPAS1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Endothelial PAS Domain Protein 1 (EPAS1) (AA 21-336) antibodyEPAS1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Endothelial PAS Domain Protein 1 (EPAS1) (Ser343) antibodyEPAS1 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Endothelial PAS Domain Protein 1 (EPAS1) (AA 680-870) antibodyEPAS1 适用: 人 IHC, ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 1H3E12 unconjugated
anti-Endothelial PAS Domain Protein 1 (EPAS1) (C-Term) antibodyEPAS1 适用: 人, 大鼠, 小鼠, 鱼 WB, IHC, ELISA, IP, ICC, FACS, IF, ChIP, GS 宿主: 兔 Polyclonal unconjugated
anti-Endothelial PAS Domain Protein 1 (EPAS1) (AA 28-347) antibodyEPAS1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1G2 unconjugated
anti-Endothelial PAS Domain Protein 1 (EPAS1) (AA 588-870) antibodyEPAS1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Endothelial PAS Domain Protein 1 (EPAS1) antibodyEPAS1 适用: 人 WB, ChIP 宿主: 兔 Polyclonal unconjugated
anti-Endothelial PAS Domain Protein 1 (EPAS1) (AA 535-631) antibodyEPAS1 适用: 人, 大鼠, 小鼠, Hamster WB, IHC, ELISA, IP, ICC, FACS, IF, ChIP 宿主: 小鼠 Monoclonal ep190b unconjugated
anti-Endothelial PAS Domain Protein 1 (EPAS1) (AA 1-130) antibodyEPAS1 适用: 人, 大鼠, 小鼠, 猴, 绵羊 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 870 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- EPAS1 (Endothelial PAS Domain Protein 1 (EPAS1))
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别名
- EPAS1
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背景
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EPAS1 is a transcription factor involved in the induction of oxygen regulated genes. EPAS1 binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. EPAS1 regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. EPAS1 may also play a role in the formation of the endothelium that gives rise to the blood brain barrier. EPAS1 is a potent activator of the Tie-2 tyrosine kinase expression. The activation seems to require recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction of EPAS1 with redox regulatory protein APEX seems to activate CTAD.
Alias Symbols: HIF2A, HLF, MOP2, PASD2, ECYT4, bHLHe73
Protein Interaction Partner: MAP1LC3A, SQSTM1, LAMP1, BATF2, BATF3, BATF, DDIT3, DBP, NDN, JUN, EPAS1, NPM1, BBS4, BBS2, BBS1, Arnt, VHL, STAT5A, SMAD3, EWSR1, MED11, MED8, EGLN3, PSMD1, PSMB1, MED1, PHB, MITF, HIF1A, EP300, EMD, CTNNB1, CREBBP, EGLN2, DPY30, MED10, MED25, ARID1B, WR
Protein Size: 870 -
分子量
- 90 kDa
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基因ID
- 2034
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NCBI登录号
- NM_001430, NP_001421
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UniProt
- Q99814
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途径
- Signaling Events mediated by VEGFR1 and VEGFR2, Warburg Effect
抗原
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