MBD2 抗体 (Middle Region)
Quick Overview for MBD2 抗体 (Middle Region) (ABIN2778640)
抗原
See all MBD2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Middle Region
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序列
- DCPALPPGWK KEEVIRKSGL SAGKSDVYYF SPSGKKFRSK PQLARYLGNT
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预测反应
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%
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产品特性
- This is a rabbit polyclonal antibody against MBD2. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
- Protein A purified
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免疫原
- The immunogen is a synthetic peptide directed towards the middle region of human MBD2
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anti-Methyl-CpG Binding Domain Protein 2 (MBD2) (Internal Region) antibody
Verified MBD2 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Methyl-CpG Binding Domain Protein 2 (MBD2) (AA 250-279) antibodyMBD2 适用: 人 WB, IF 宿主: 兔 Polyclonal RB41663 unconjugated
anti-Methyl-CpG Binding Domain Protein 2 (MBD2) (N-Term) antibodyMBD2 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Methyl-CpG Binding Domain Protein 2 (MBD2) (AA 145-411) antibodyMBD2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Methyl-CpG Binding Domain Protein 2 (MBD2) (AA 10-228) antibodyMBD2 适用: 人 WB, IHC (p) 宿主: 小鼠 Monoclonal 1812CT625-9-45 unconjugated
anti-Methyl-CpG Binding Domain Protein 2 (MBD2) (AA 202-411) antibodyMBD2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Methyl-CpG Binding Domain Protein 2 (MBD2) antibodyMBD2 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Methyl-CpG Binding Domain Protein 2 (MBD2) (Center) antibodyMBD2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Methyl-CpG Binding Domain Protein 2 (MBD2) (N-Term) antibodyMBD2 适用: 人, 小鼠, 大鼠, Bat, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Methyl-CpG Binding Domain Protein 2 (MBD2) (AA 361-411) antibodyMBD2 适用: 人, 小鼠, 犬, 豚鼠, Pig WB, IHC, IP, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 302 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- MBD2 (Methyl-CpG Binding Domain Protein 2 (MBD2))
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别名
- MBD2
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背景
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MBD2 belongs to a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MBD2 can also repress transcription from methylated gene promoters. MBD2 may function as a mediator of the biological consequences of the methylation signal.It is also reported that the MBD2 functions as a demethylase to activate transcription, as DNA methylation causes gene silencing.DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing.
Alias Symbols: DMTase, NY-CO-41
Protein Interaction Partner: UBC, SOX2, HDAC2, HDAC1, MTA3, LAMTOR3, TFAP4, KDM5B, CDK2AP1, ESR1, KDM1A, MTA2, MBD2, RBBP7, RBBP4, CHD3, tat, MBD3L2, MBD3, csul, GATAD2A, TACC3, PRMT5, WDR77, PRMT1, PTK2B, TRIM27, GATAD2B, MBD3L1, GPN1, SIN3A, HINFP, DHX9, CREBBP, DNMT1, tax, NEWENTR
Protein Size: 302 -
分子量
- 32 kDa
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基因ID
- 8932
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NCBI登录号
- NM_015832, NP_056647
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途径
- Chromatin Binding
抗原
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