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NOTCH2 抗体 (Middle Region)

This anti-NOTCH2 antibody is a 兔 多克隆 antibody detecting NOTCH2 in WB. Suitable for 人, 小鼠, 大鼠, 犬, Pig, 兔, Cow 和 豚鼠. This Primary Antibody has been cited in 1 publication.
产品编号 ABIN2777549
发货至: 中国

Quick Overview for NOTCH2 抗体 (Middle Region) (ABIN2777549)

抗原

See all NOTCH2 抗体
NOTCH2 (Notch 2 (NOTCH2))

适用

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人, 小鼠, 大鼠, 犬, Pig, 兔, Cow, 豚鼠

宿主

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克隆类型

  • 75
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多克隆

标记

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This NOTCH2 antibody is un-conjugated

应用范围

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Western Blotting (WB)
  • 抗原表位

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    Middle Region

    序列

    FPASVGKYPT PPSQHSYASS NAAERTPSHS GHLQGEHPYL TPSPESPDQW

    预测反应

    Cow: 100%, Dog: 100%, Guinea Pig: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 93%

    产品特性

    This is a rabbit polyclonal antibody against NOTCH2. It was validated on Western Blot using a cell lysate as a positive control.

    纯化方法

    Affinity Purified

    免疫原

    The immunogen is a synthetic peptide directed towards the middle region of human NOTCH2
  • 应用备注

    Optimal working dilutions should be determined experimentally by the investigator.

    说明

    Antigen size: 2471 AA

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    Lot specific

    缓冲液

    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freeze-thaw cycles.

    储存条件

    -20 °C

    储存方法

    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Tilley, Harvey, Heguy, Hackett, Wang, OConnor, Crystal: "Down-regulation of the notch pathway in human airway epithelium in association with smoking and chronic obstructive pulmonary disease." in: American journal of respiratory and critical care medicine, Vol. 179, Issue 6, pp. 457-66, (2009) (PubMed).

  • 抗原

    NOTCH2 (Notch 2 (NOTCH2))

    别名

    NOTCH2

    背景

    NOTCH2 is a member of the Notch family. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. NOTCH2 is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. NOTCH2 functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development.This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
    Alias Symbols: AGS2, hN2, HJCYS
    Protein Interaction Partner: ASB14, EGFL7, LATS2, ANKRD28, UBC, SMAD1, NOTCH1, SIN3A, SPEN, SEC24C, TJP1, PSMB1, PLAUR, PCMT1, NDUFV2, NDUFV1, MYOC, CRKL, MAML3, MAML2, CNTN1, DLL1, MAML1, GSK3B, DTX1, MFNG, LFNG, JAG2, JAG1, PSEN2, RBPJ, PSEN1, tat,
    Protein Size: 2471

    分子量

    85 kDa

    基因ID

    4853

    NCBI登录号

    NM_024408, NP_077719

    UniProt

    Q04721

    途径

    Notch Signaling, Stem Cell Maintenance
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