UPF3B 抗体 (Middle Region)
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北京 101111
Quick Overview for UPF3B 抗体 (Middle Region) (ABIN2776615)
抗原
See all UPF3B 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Middle Region
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序列
- KIDRIPERDK LKDEPKIKVH RFLLQAVNQK NLLKKPEKGD EKELDKREKA
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预测反应
- Dog: 100%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 100%, Rat: 100%
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产品特性
- This is a rabbit polyclonal antibody against UPF3B. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the middle region of human UPF3B
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anti-UPF3 Regulator of Nonsense Transcripts Homolog B (UPF3B) (AA 416-452), (C-Term) antibody
UPF3B 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-UPF3 Regulator of Nonsense Transcripts Homolog B (UPF3B) (AA 319-423) antibodyUPF3B 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-UPF3 Regulator of Nonsense Transcripts Homolog B (UPF3B) (N-Term) antibodyUPF3B 适用: 人, Cow WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-UPF3 Regulator of Nonsense Transcripts Homolog B (UPF3B) antibodyUPF3B 适用: 人, 犬 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-UPF3 Regulator of Nonsense Transcripts Homolog B (UPF3B) (N-Term) antibodyUPF3B 适用: 人, 小鼠, 大鼠, 犬, 兔, Pig, Cow WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-UPF3 Regulator of Nonsense Transcripts Homolog B (UPF3B) (AA 252-301) antibodyUPF3B 适用: 人, 犬, 兔, 猴 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 483 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- UPF3B (UPF3 Regulator of Nonsense Transcripts Homolog B (UPF3B))
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别名
- UPF3B
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背景
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UPF3B is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The protein is one of two functional homologs to yeast Upf3p. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene.
Alias Symbols: HUPF3B, MRXS14, RENT3B, UPF3X
Protein Interaction Partner: NCBP1, CIAO1, STAU1, UBC, UPF1, HECW2, RBM8A, UPF2, SMG1, EIF4A3, WIBG, WBP11, RNPS1, SART1, TOP2A, SNRPA1, NXF1, CAND1, COPS5, CUL5, USP21, EXOSC4, MCRS1, XRN1, TTC19, EIF6, UPF3B, HBB, UPF3A,
Protein Size: 483 -
分子量
- 58 kDa
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基因ID
- 65109
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NCBI登录号
- NM_080632, NP_542199
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UniProt
- Q9BZI7
抗原
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