TIA1 抗体 (N-Term)
Quick Overview for TIA1 抗体 (N-Term) (ABIN2776555)
抗原
See all TIA1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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序列
- MGKEVKVNWA TTPSSQKKDT SSSTVVSTQR SQDHFHVFVG DLSPEITTED
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预测反应
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%
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产品特性
- This is a rabbit polyclonal antibody against TIA1. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the N terminal region of human TIA1
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 386 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- TIA1 (TIA1 Cytotoxic Granule-Associated RNA Binding Protein (TIA1))
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别名
- TIA1
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背景
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TIA1 is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15- kDa protein that is thought to be derived from the carboxyl terminus of the 40- kDa product by proteolytic processing. The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15- kDa protein that is thought to be derived from the carboxyl terminus of the 40- kDa product by proteolytic processing. Alternative splicing resulting in different isoforms of this gene product has been described in the literature.
Alias Symbols: TIA-1
Protein Interaction Partner: NEDD8, BMI1, SOX2, VCAM1, ITGA4, FN1, FMNL1, WDR6, SRSF3, CAND1, DCUN1D1, COPS5, CUL1, CUL2, CUL3, CUL4A, CUL5, Rc3h1, UBC, RICTOR, FASTK,
Protein Size: 386 -
分子量
- 43 kDa
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基因ID
- 7072
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NCBI登录号
- NM_022173, NP_071505
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UniProt
- P31483
抗原
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