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Parkin 抗体 (C-Term)

Name: Parkin 抗体 (C-Term)
SKU: ABIN2775689
Availability: OutOfStock

This anti-Parkin antibody is a 兔多克隆 antibody detecting Parkin in WB. Suitable for 人, 小鼠, 大鼠, Cow, Pig 和犬.

WB Suggested Anti-Park2 Antibody Titration: 0. (Parkin 抗体 (C-Term))

1 image

产品编号 ABIN2775689

发货至: 中国

Quick Overview for Parkin 抗体 (C-Term) (ABIN2775689)

抗原

See all Parkin (PARK2) 抗体

Parkin (PARK2) (Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2))

适用

人, 小鼠, 大鼠, Cow, Pig, 犬

宿主

兔

克隆类型

多克隆

标记

This Parkin antibody is un-conjugated

应用范围

Western Blotting (WB)

Discover our top product PARK2 Primary Antibody

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C-Term

序列

YTRYQQYGAE ECVLQMGGVL CPRPGCGAGL LPEQGQRKVT CEGGNGLGCG

预测反应

Cow: 92%, Dog: 86%, Human: 100%, Mouse: 86%, Pig: 93%, Rat: 86%

产品特性

This is a rabbit polyclonal antibody against Park2. It was validated on Western Blot.

纯化方法

Affinity Purified

免疫原

The immunogen is a synthetic peptide corresponding to a region of Mouse
anti-Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) (AA 288-387) antibody
PARK2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1H4 unconjugated

anti-Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) (AA 1-300) antibody
PARK2 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) (AA 387-417), (C-Term) antibody
PARK2 适用: 人, 小鼠 WB, IF, FACS, IHC (p) 宿主: 兔 Polyclonal RB07373 unconjugated

anti-Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) (AA 387-417) antibody
PARK2 适用: 人, 小鼠 WB, ELISA, IHC, IF, FACS 宿主: 兔 Polyclonal unconjugated

anti-Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) (AA 111-140) antibody
PARK2 适用: 人 WB, ELISA, IHC, IF, FACS 宿主: 兔 Polyclonal unconjugated

anti-Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) (AA 361-465) antibody
PARK2 适用: 大鼠 WB, ELISA, IF (cc), IF (p), FACS, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) (AA 1-465) antibody
PARK2 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) (AA 1-144) antibody
PARK2 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 6F5D2 unconjugated

anti-Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) (AA 23-416) antibody
PARK2 适用: 人, 小鼠, 大鼠 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated

anti-Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) (AA 311-360) antibody
PARK2 适用: 人, 小鼠, 大鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

应用备注

Optimal working dilutions should be determined experimentally by the investigator.

说明

Antigen size: 464 AA

限制

仅限研究用
状态

Liquid

浓度

Lot specific

缓冲液

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freeze-thaw cycles.

储存条件

-20 °C

储存方法

For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
抗原

Parkin (PARK2) (Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2))

别名

Park2

背景

Park2 functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include SYT11, CCNE1, GPR37, STUB1, a 22 kDa O-linked glycosylated isoform of SNCAIP, SEPT5 and AIMP2. Park2 may play a more general role in the ubiquitin proteasomal pathway by participating in the removal and/or detoxification of abnormally folded or damaged protein. Park2 limits the production of reactive oxygen species (ROS). Loss of this ubiquitin ligase activity appears to be the mechanism underlying pathogenesis of AR-JP. Park2 may protect neurons against alpha synuclein toxicity, proteasomal dysfunction, GPR37 accumulation, and kainate-induced excitotoxicity. Park2 may play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. Park2 regulates cyclin E during neuronal apoptosis. Park2 may represent a tumor suppressor gene. Park2 promotes the autophagic degradation of dysfunctional depolarized mitochondria.
Alias Symbols: MGC130518, PRKN
Protein Interaction Partner: Becn1, Actb, Hdac6, TARDBP, Bax, Acta1, Ubc, Prps1, SNCA, Sh3gl2, Eps15, Synj1, Sh3gl3, Sh3gl1, Ambra1, Pick1, Cask, Abl1, Bcl2,
Protein Size: 464

分子量

51 kDa

基因ID

50873

NCBI登录号

NM_016694, NP_057903

UniProt

Q9WVS6

途径

Autophagy, Ubiquitin Proteasome Pathway