BTRC 抗体 (C-Term)
Quick Overview for BTRC 抗体 (C-Term) (ABIN2775273)
抗原
See all BTRC 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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序列
- LVEHSGRVFR LQFDEFQIVS SSHDDTILIW DFLNDPAAHA EPPRSPSRTY
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预测反应
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 86%
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产品特性
- This is a rabbit polyclonal antibody against Btrc. It was validated on Western Blot.
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纯化方法
- Affinity Purified
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anti-beta-Transducin Repeat Containing (BTRC) (AA 24-151) antibody
BTRC 适用: 人 WB, ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 4C5D8 unconjugated
anti-beta-Transducin Repeat Containing (BTRC) (AA 50-340) antibodyBTRC 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-beta-Transducin Repeat Containing (BTRC) antibodyBTRC 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-beta-Transducin Repeat Containing (BTRC) (AA 397-448) antibodyBTRC 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-beta-Transducin Repeat Containing (BTRC) (AA 1-605) antibodyBTRC 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-beta-Transducin Repeat Containing (BTRC) (N-Term) antibodyBTRC 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-beta-Transducin Repeat Containing (BTRC) (AA 52-354) antibodyBTRC 适用: 人 WB, IF, FACS 宿主: 小鼠 Monoclonal 2H2 unconjugated
anti-beta-Transducin Repeat Containing (BTRC) (AA 17-52), (N-Term) antibodyBTRC 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB16275 unconjugated
anti-beta-Transducin Repeat Containing (BTRC) antibodyBTRC 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated
anti-beta-Transducin Repeat Containing (BTRC) (AA 701-1000) antibodyBTRC 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 605 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- BTRC (beta-Transducin Repeat Containing (BTRC))
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别名
- Btrc
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背景
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Btrc is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE, the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22'. SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1/nuclear factor NF-kappa-B p105 subunit, ATF4, SMAD3, SMAD4, CDC25A, DLG1, FBXO5 and probably NFKB2. SCF(BTRC) mediates the ubiquitination of phosphorylated SNAI1.
Alias Symbols: Beta-Trcp1, FWD1, Fbw1a, KIAA4123, Slimb, b-TrCP, beta-TrCP, mKIAA4123, HOS
Protein Interaction Partner: ZRANB1, Tpx2, Taz, Per2, Cul1, Skp1a, Reg1, Stat1, Nfe2l2, Per1, Htt, Cops2, Ikbkb, Nkx3-2, Cdc25b, Nfkbia, Gli2,
Protein Size: 605 -
分子量
- 69 kDa
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基因ID
- 12234
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NCBI登录号
- NM_001037758, NP_001032847
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UniProt
- Q3ULA2
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途径
- Cell Division Cycle, Hedgehog Signaling
抗原
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