MCM10 抗体 (Middle Region)
Quick Overview for MCM10 抗体 (Middle Region) (ABIN2774890)
抗原
See all MCM10 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Middle Region
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序列
- PKLSALAEAK KLAAITKLRA KGQVLTKTNP NSIKKKQKDP QDILEVKERV
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预测反应
- Cow: 77%, Dog: 86%, Horse: 93%, Human: 100%, Pig: 77%, Rabbit: 86%
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产品特性
- This is a rabbit polyclonal antibody against MCM10. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the middle region of human MCM10
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anti-Minichromosome Maintenance Deficient 10 (MCM10) (C-Term) antibody
MCM10 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Minichromosome Maintenance Deficient 10 (MCM10) (AA 1-874) antibodyMCM10 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Minichromosome Maintenance Deficient 10 (MCM10) antibodyMCM10 适用: 人, 小鼠 IF 宿主: 兔 Polyclonal unconjugated
anti-Minichromosome Maintenance Deficient 10 (MCM10) antibodyMCM10 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Minichromosome Maintenance Deficient 10 (MCM10) (AA 1-874) antibodyMCM10 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Minichromosome Maintenance Deficient 10 (MCM10) (AA 40-89) antibodyMCM10 适用: 人, 小鼠, 大鼠, 犬, 猴, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Minichromosome Maintenance Deficient 10 (MCM10) (AA 648-697) antibodyMCM10 适用: 人, 犬, Cow, 兔, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Minichromosome Maintenance Deficient 10 (MCM10) (AA 616-875) antibodyMCM10 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Minichromosome Maintenance Deficient 10 (MCM10) (N-Term) antibodyMCM10 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Minichromosome Maintenance Deficient 10 (MCM10) antibodyMCM10 适用: 人 WB, IF, IC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 874 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- MCM10 (Minichromosome Maintenance Deficient 10 (MCM10))
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别名
- MCM10
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背景
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This protein is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding.The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified.
Alias Symbols: CNA43, MGC126776, PRO2249, DNA43
Protein Interaction Partner: GOLGA2, MCM6, TRIM37, CCND3, ORC3, CDC45, CDC7, UBC, ORC4, ORC2, MCM7, MCM3, MCM2, CDKN2A, CDKN1A, CDK6, CDC6, CDC5L, CCND1, APP, RBX1, VPRBP, CUL4A, DDB1, IKBKG, RPAP1, CEP70, HAUS1, CCDC85B, DPPA2, NINL, ZBTB8B, HOOK2, MCM4, ZBTB43, CEP72, CALCOCO2, KRT
Protein Size: 874 -
分子量
- 98 kDa
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基因ID
- 55388
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NCBI登录号
- NM_018518, NP_060988
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UniProt
- B7ZKZ8
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途径
- Mitotic G1-G1/S Phases, DNA Replication
抗原
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