PHLPP1 抗体
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北京 101111
Quick Overview for PHLPP1 抗体 (ABIN2764065)
抗原
See all PHLPP1 抗体适用
宿主
克隆类型
标记
应用范围
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交叉反应
- 人
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产品特性
- KIAA0606, PHLPP, PLEKHE1, SCOP, PHLPP1, PH domain leucine-rich repeat-containing protein phosphatase 1, Pleckstrin homology domain-containing family E member 1, Suprachiasmatic nucleus circadian oscillatory protein,PHLPP1 is a 1717 aa protein with phosphatase activity that mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and suppression of tumor growth. Controls the phosphorylation of AKT2 and AKT3 more efficiently than that of AKT1. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Inhibits cancer cell proliferation and may act as a tumor suppressor. May act as a negative regulator of K-Ras signaling in membrane rafts.
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纯化方法
- Antigen Immunoaffinity Purification
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免疫原
- Synthetic peptide derived from the human PHLPP1 protein
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亚型
- Ig Fraction
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anti-PH Domain and Leucine Rich Repeat Protein Phosphatase 1 (PHLPP1) (AA 1508-1717) antibody
PHLPP1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-PH Domain and Leucine Rich Repeat Protein Phosphatase 1 (PHLPP1) antibodyPHLPP1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-PH Domain and Leucine Rich Repeat Protein Phosphatase 1 (PHLPP1) (C-Term) antibodyPHLPP1 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-PH Domain and Leucine Rich Repeat Protein Phosphatase 1 (PHLPP1) (N-Term) antibodyPHLPP1 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-PH Domain and Leucine Rich Repeat Protein Phosphatase 1 (PHLPP1) antibodyPHLPP1 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal concentration should be evaluated by serial dilutions.
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限制
- 仅限研究用
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缓冲液
- Provided as solution in phosphate buffered saline with 0.08 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
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- PHLPP1 (PH Domain and Leucine Rich Repeat Protein Phosphatase 1 (PHLPP1))
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别名
- PH Domain-containing family E member 1
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UniProt
- O60346
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途径
- PI3K-Akt Signaling, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway
抗原
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