PHLPP1 抗体 (N-Term)
Our Local Distributor
北京 101111
Quick Overview for PHLPP1 抗体 (N-Term) (ABIN6991746)
抗原
See all PHLPP1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 250-300, N-Term
-
特异性
- At least four isoforms are known to exist, this antibody will only detect the largest isoform. PHLPP1 antibody is predicted to not cross react with PHLPP2.
-
纯化方法
- PHLPP1 Antibody is affinity chromatography purified via peptide column.
-
免疫原
- PHLPP1 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human PHLPP1. The immunogen is located within amino acids 250 - 300 of PHLPP1.
-
亚型
- IgG
-
-
anti-PH Domain and Leucine Rich Repeat Protein Phosphatase 1 (PHLPP1) (AA 1508-1717) antibody
PHLPP1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-PH Domain and Leucine Rich Repeat Protein Phosphatase 1 (PHLPP1) antibodyPHLPP1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-PH Domain and Leucine Rich Repeat Protein Phosphatase 1 (PHLPP1) (C-Term) antibodyPHLPP1 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-PH Domain and Leucine Rich Repeat Protein Phosphatase 1 (PHLPP1) (N-Term) antibodyPHLPP1 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-PH Domain and Leucine Rich Repeat Protein Phosphatase 1 (PHLPP1) antibodyPHLPP1 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
PHLPP1 antibody can be used for detection of PHLPP1 by Western blot at 1 - 2 μ,g/mL.
Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. -
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 mg/mL
-
缓冲液
- PHLPP1 Antibody is supplied in PBS containing 0.02 % sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C,4 °C
-
储存方法
- PHLPP1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
-
-
- PHLPP1 (PH Domain and Leucine Rich Repeat Protein Phosphatase 1 (PHLPP1))
-
别名
- PHLPP1
-
背景
- PHLPP1 Antibody: PHLPP1 is a member of the serine/threonine phosphatase family, which are important regulators of Akt serine-threonine kinases (AKT1, AKT2, AKT3) and conventional/novel protein kinase C (PKC) isoforms. PHLPP1 and PHLPP2 have a similar domain structure and have been shown to dephosphorylate and inactivate, distinct Akt isoforms, at one of the two critical phosphorylation sites required for activation: Serine473. PHLPP2 dephosphorylates AKT1 and AKT3, whereas PHLPP1 is specific for AKT2 and AKT3. PHLPP1 promotes apoptosis and may act as a tumor suppressor. Increased expression of PHLPP1 may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling.
-
分子量
- 189 kDa
-
基因ID
- 23239
-
NCBI登录号
- NP_919431
-
UniProt
- O60346
-
途径
- PI3K-Akt Signaling, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway
抗原
-
