CD42b 抗体
Quick Overview for CD42b 抗体 (ABIN2752001)
抗原
See all CD42b (GP1BA) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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                                            原理
- Anti-Hu CD42b Purified Low Endotoxin
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                                            特异性
- The mouse monoclonal antibody AK2 recognizes an extracellular epitope of CD42b (GPIb alpha), a 135-145 kDa membrane glycoprotein expressed on platelets and megakaryocytes. CD42b and CD42c (GPIb beta) are composed in a disulfide linked heterodimer (CD42b/c, 160 kDa), CD42b/c forms a noncovalent complex with CD42a and CD42d.
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                                            交叉反应 (详细)
- Human
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                                            纯化方法
- Purified by protein-A affinity chromatography.
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                                            纯度
- > 95 % (by SDS-PAGE)
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                                            内毒素水平
- Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test.
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                                            免疫原
- Human platelets
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                                            亚型
- IgG1
 
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                                            应用备注
- Flow cytometry: Recommended dilution: 1-4 μg/mL.
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                                            限制
- 仅限研究用
 
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                                            浓度
- 1 mg/mL
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                                            缓冲液
- Phosphate buffered saline (PBS), pH 7.4
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                                            储存条件
- 4 °C
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                                            储存方法
- Store at 2-8°C. Do not freeze.
 
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    - 
                                            : "Platelet-targeting sensor reveals thrombin gradients within blood clots forming in microfluidic assays and in mouse."    in: Journal of thrombosis and haemostasis : JTH, Vol. 10, Issue 11, pp. 2344-53, (2014)         (PubMed).        
 : "Novel point mutation in a leucine-rich repeat of the GPIbalpha chain of the platelet von Willebrand factor receptor, GPIb/IX/V, resulting in an inherited dominant form of Bernard-Soulier syndrome ..." in: Haematologica, Vol. 93, Issue 11, pp. 1743-7, (2008) (PubMed).
 
 
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                                            : "Platelet-targeting sensor reveals thrombin gradients within blood clots forming in microfluidic assays and in mouse."    in: Journal of thrombosis and haemostasis : JTH, Vol. 10, Issue 11, pp. 2344-53, (2014)         (PubMed).        
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    - CD42b (GP1BA) (Glycoprotein Ib (Platelet), alpha Polypeptide (GP1BA))
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                                            别名
- CD42b
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                                            背景
- Glycoprotein Ib platelet subunit alpha,CD42b (GPIb alpha) composes together with GPIb beta, GPIX and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular weight kininogen, TSP-1, integrin Mac-1 and P-selectin. The extracellular domain of CD42b by its interactions also contributes to metastasis.,BSS, GP1B, VWDP, CD42B, GPIbA, BDPLT1, BDPLT3, DBPLT3
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                                            基因ID
- 2811
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                                            UniProt
- P07359
 抗原
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