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CD42b 抗体

This anti-CD42b antibody is a 小鼠 单克隆 antibody detecting CD42b in FACS, WB, ELISA, IP 和 ICC. Suitable for 人. This Primary Antibody has been cited in 2+ publications.
产品编号 ABIN2752001
发货至: 中国

Quick Overview for CD42b 抗体 (ABIN2752001)

抗原

See all CD42b (GP1BA) 抗体
CD42b (GP1BA) (Glycoprotein Ib (Platelet), alpha Polypeptide (GP1BA))

适用

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宿主

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小鼠

克隆类型

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单克隆

标记

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This CD42b antibody is un-conjugated

应用范围

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Flow Cytometry (FACS), Western Blotting (WB), ELISA, Immunoprecipitation (IP), Immunocytochemistry (ICC)

克隆位点

AK2
  • 原理

    Anti-Hu CD42b Purified Low Endotoxin

    特异性

    The mouse monoclonal antibody AK2 recognizes an extracellular epitope of CD42b (GPIb alpha), a 135-145 kDa membrane glycoprotein expressed on platelets and megakaryocytes. CD42b and CD42c (GPIb beta) are composed in a disulfide linked heterodimer (CD42b/c, 160 kDa), CD42b/c forms a noncovalent complex with CD42a and CD42d.

    交叉反应 (详细)

    Human

    纯化方法

    Purified by protein-A affinity chromatography.

    纯度

    > 95 % (by SDS-PAGE)

    内毒素水平

    Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test.

    免疫原

    Human platelets

    亚型

    IgG1
  • 应用备注

    Flow cytometry: Recommended dilution: 1-4 μg/mL.

    限制

    仅限研究用
  • 浓度

    1 mg/mL

    缓冲液

    Phosphate buffered saline (PBS), pH 7.4

    储存条件

    4 °C

    储存方法

    Store at 2-8°C. Do not freeze.
  • Welsh, Colace, Muthard, Stalker, Brass, Diamond: "Platelet-targeting sensor reveals thrombin gradients within blood clots forming in microfluidic assays and in mouse." in: Journal of thrombosis and haemostasis : JTH, Vol. 10, Issue 11, pp. 2344-53, (2014) (PubMed).

    Vettore, Scandellari, Moro, Lombardi, Scapin, Randi, Fabris et al.: "Novel point mutation in a leucine-rich repeat of the GPIbalpha chain of the platelet von Willebrand factor receptor, GPIb/IX/V, resulting in an inherited dominant form of Bernard-Soulier syndrome ..." in: Haematologica, Vol. 93, Issue 11, pp. 1743-7, (2008) (PubMed).

  • 抗原

    CD42b (GP1BA) (Glycoprotein Ib (Platelet), alpha Polypeptide (GP1BA))

    别名

    CD42b

    背景

    Glycoprotein Ib platelet subunit alpha,CD42b (GPIb alpha) composes together with GPIb beta, GPIX and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular weight kininogen, TSP-1, integrin Mac-1 and P-selectin. The extracellular domain of CD42b by its interactions also contributes to metastasis.,BSS, GP1B, VWDP, CD42B, GPIbA, BDPLT1, BDPLT3, DBPLT3

    基因ID

    2811

    UniProt

    P07359
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