DLL4 抗体
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北京 101111
Quick Overview for DLL4 抗体 (ABIN2749212)
抗原
See all DLL4 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Anti-DLL4 Purified Low Endotoxin
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特异性
- The mouse monoclonal antibody MHD4-46 recognizes the extracellular domain of DLL4 (Delta-like ligand 4), a type I transmembrane protein which plays an important role in vascular development.
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交叉反应 （详细）
- Human
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纯化方法
- Purified by protein-A affinity chromatography.
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纯度
- > 95 % (by SDS-PAGE)
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内毒素水平
- Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test.
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免疫原
- recombinant soluble human DLL4
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亚型
- IgG1 kappa
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anti-delta-Like 4 (DLL4) (AA 313-439) antibody
DLL4 适用: 人 ELISA, IHC 宿主: 小鼠 Monoclonal 4A11F8 unconjugated
anti-delta-Like 4 (DLL4) antibodyDLL4 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 4A11G2 unconjugated
anti-delta-Like 4 (DLL4) (AA 215-331) antibodyDLL4 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-delta-Like 4 (DLL4) antibodyDLL4 适用: 人 WB, ELISA, IHC, IHC (p) 宿主: 小鼠 Monoclonal 4A11F8 unconjugated
anti-delta-Like 4 (DLL4) antibodyDLL4 适用: 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-delta-Like 4 (DLL4) (Internal Region) antibodyDLL4 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-delta-Like 4 (DLL4) antibodyDLL4 适用: 人 WB, EIA 宿主: 小鼠 Monoclonal 4A11F8-4A11G2 unconjugated
anti-delta-Like 4 (DLL4) (AA 44-345) antibodyDLL4 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-delta-Like 4 (DLL4) (AA 123-221) antibodyDLL4 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-delta-Like 4 (DLL4) antibody (PE)DLL4 适用: 小鼠 FACS 宿主: 仓鼠 Monoclonal HMD4-2 PE
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应用备注
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Functional application: Blocking.
Flow cytometry: Recommended dilution: 1-4 μg/mL -
限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH 7.4
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储存条件
- 4 °C
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储存方法
- Store at 2-8°C. Do not freeze.
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: "Differential regulation of osteoclastogenesis by Notch2/Delta-like 1 and Notch1/Jagged1 axes." in: Arthritis research & therapy, Vol. 14, Issue 2, pp. R45, (2012) (PubMed).
: "Blockade of delta-like ligand 4 signaling inhibits both growth and angiogenesis of pancreatic cancer." in: Pancreas, Vol. 39, Issue 6, pp. 897-903, (2010) (PubMed).
: "Role of ephrinB2 in nonproductive angiogenesis induced by Delta-like 4 blockade." in: Blood, Vol. 113, Issue 15, pp. 3631-9, (2009) (PubMed).
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: "Differential regulation of osteoclastogenesis by Notch2/Delta-like 1 and Notch1/Jagged1 axes." in: Arthritis research & therapy, Vol. 14, Issue 2, pp. R45, (2012) (PubMed).
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- DLL4 (delta-Like 4 (DLL4))
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别名
- DLL4
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背景
- Delta like canonical Notch ligand 4,DLL4 (Delta-like 4) is one of five ligands of Notch receptors. It interacts with Notch1 and Notch4. DLL4 is up-regulated at sites of physiologic and pathologic angiogenesis, whereas its expression is low in most adult normal tissues. It is also highly expressed in human clear-cell renal carcinomas, bladder cancers, and breast cancers. Blocking the DLL4-Notch interaction seems to be a promissing therapeutic approach.,Delta like ligand 4, AOS6, canonical Notch ligand 4
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基因ID
- 54567
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UniProt
- Q9NR61
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途径
- Notch Signaling
抗原
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