TNFRSF4 抗体 (PE)
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北京 101111
Quick Overview for TNFRSF4 抗体 (PE) (ABIN2749174)
抗原
See all TNFRSF4 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Anti-Hu CD134 PE
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交叉反应 （详细）
- Human, Non-Human Primates
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产品特性
- The mouse monoclonal antibody Ber-ACT35 (also known as ACT35) recognizes an extracellular epitope of CD134 (TNFRSF4, OX40), an approximately 50 kDa type I transmembrane glycoprotein expressed on activated T cells.
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纯化方法
- Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
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免疫原
- HTLV 1-transformed HUT-102 cells
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亚型
- IgG1, kappa
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anti-Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) (AA 59-205) antibody
TNFRSF4 适用: 人, Chimpanzee FACS, ELISA, IHC, IF, Coat, ISt, StM 宿主: 小鼠 Monoclonal OX40-3108 unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) (AA 29-214) antibodyTNFRSF4 适用: 人 FACS, ELISA, IHC 宿主: 小鼠 Monoclonal 3G5G7 unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) antibody (FITC)TNFRSF4 适用: 人, Non-Human Primate FACS 宿主: 小鼠 Monoclonal Ber-ACT35 FITC
anti-Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) antibody (APC)TNFRSF4 适用: 人, Non-Human Primate FACS 宿主: 小鼠 Monoclonal Ber-ACT35 APC
anti-Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) (AA 29-214) antibodyTNFRSF4 适用: 人 FACS, ELISA 宿主: 小鼠 Monoclonal 2D1B8 unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) (AA 101-200) antibodyTNFRSF4 适用: 人, 小鼠, 大鼠 WB, ELISA, ICC, IHC (fro), IF (p), IF (cc), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) antibodyTNFRSF4 适用: 大鼠 FACS, IP, IHC (fro) 宿主: 小鼠 Monoclonal OX-40 unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) antibodyTNFRSF4 适用: 人, Cat WB, FACS 宿主: 小鼠 Monoclonal 7D6 unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) antibodyTNFRSF4 适用: 小鼠 FACS, IHC (fro) 宿主: 大鼠 Monoclonal OX-86 unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) antibodyTNFRSF4 适用: 人, Non-Human Primate WB, FACS, ELISA, IP, IHC (fro), IHC (p) 宿主: 小鼠 Monoclonal Ber-ACT35 unconjugated
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应用备注
- Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Do not freeze,Protect from prolonged exposure to light
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储存条件
- 4 °C
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储存方法
- Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
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: "Antibodies targeting human OX40 expand effector T cells and block inducible and natural regulatory T cell function." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 191, Issue 7, pp. 3641-50, (2013) (PubMed).
: "Hodgkin's reed-sternberg cell line (KM-H2) promotes a bidirectional differentiation of CD4+CD25+Foxp3+ T cells and CD4+ cytotoxic T lymphocytes from CD4+ naive T cells." in: Journal of leukocyte biology, Vol. 82, Issue 3, pp. 576-84, (2007) (PubMed).
: "The effect of anti-human CD134 monoclonal antibody on phytohemagglutinin-induced mRNA expression of perforin in peripheral blood mononuclear cells." in: Cellular & molecular immunology, Vol. 2, Issue 6, pp. 467-71, (2006) (PubMed).
: "Differential utilization of CD134 as a functional receptor by diverse strains of feline immunodeficiency virus." in: Journal of virology, Vol. 80, Issue 7, pp. 3386-94, (2006) (PubMed).
: "Coexpression of CD25 and OX40 (CD134) receptors delineates autoreactive T-cells in type 1 diabetes." in: Diabetes, Vol. 55, Issue 1, pp. 50-60, (2005) (PubMed).
: "Strong and selective glomerular localization of CD134 ligand and TNF receptor-1 in proliferative lupus nephritis." in: Journal of the American Society of Nephrology : JASN, Vol. 11, Issue 8, pp. 1426-38, (2000) (PubMed).
: "The T-cell activation markers CD30 and OX40/CD134 are expressed in nonoverlapping subsets of peripheral T-cell lymphoma." in: Blood, Vol. 93, Issue 10, pp. 3487-93, (1999) (PubMed).
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: "Antibodies targeting human OX40 expand effector T cells and block inducible and natural regulatory T cell function." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 191, Issue 7, pp. 3641-50, (2013) (PubMed).
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- TNFRSF4 (Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4))
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别名
- CD134
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背景
- TNF receptor superfamily member 4,CD134 (TNFRSF4, also known as OX40) is a type I transmembrane glycoprotein of TNF/NGF receptor family expressed on activated T cells, fibroblasts, and hematopoietic precursors. Binding to its ligand (OX40L, TNFSF4) on antigen presenting cells gives to the T cell costimulatory signal, and this interaction results also in B cell proliferation and influences T cell memory pool. CD134 is upregulated at sites of inflammation, especially in case of multiple sclerosis and psoriatic lesions.,TNFRSF4, OX40, ACT35, IMD16, TXGP1L
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基因ID
- 7293
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UniProt
- P43489
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途径
- Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints
抗原
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