MICA 抗体
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北京 101111
Quick Overview for MICA 抗体 (ABIN2749085)
抗原
See all MICA 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Anti-HLA Class I Purified
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特异性
- The antibody W6/32 recognises an extracellular epitope of MHC Class I molecules (MHC Class Ia) that are expressed on the surface of all human nucleated cell types. The antibody W6/32 is a valuable reagent for analysing variations in HLA class I expression in different disease states e.g. liver disease, muscular dystrophy, inflammatory myopathy and other neuromuscular disorders. This antibody W6/32 is also suitable as a positive control for HLA tissue typing and crossmatching.
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无交叉反应
- 兔
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交叉反应 （详细）
- Human, Non-Human Primates, Bovine, Feline (Cat)
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纯化方法
- Purified by protein-A affinity chromatography.
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纯度
- > 95 % (by SDS-PAGE)
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免疫原
- Membrane of human tonsil cells
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亚型
- IgG2a
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anti-MHC Class I Polypeptide-Related Sequence A (MICA) (AA 68-97) antibody
MICA 适用: 人 WB, FACS, IF, IHC (p) 宿主: 兔 Polyclonal RB21777 unconjugated
anti-MHC Class I Polypeptide-Related Sequence A (MICA) (AA 120-170) antibodyMICA 适用: 人 WB, IHC (p), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-MHC Class I Polypeptide-Related Sequence A (MICA) (AA 1-200) antibodyMICA 适用: 人 WB, IHC (f) 宿主: 小鼠 Monoclonal unconjugated
anti-MHC Class I Polypeptide-Related Sequence A (MICA) antibodyMICA 适用: 人 WB, FACS, IP 宿主: 小鼠 Monoclonal MEM-147 unconjugated
anti-MHC Class I Polypeptide-Related Sequence A (MICA) antibodyMICA 适用: 人, Cow, Cat, Non-Human Primate ELISA, FACS, IP, ICC, IHC (fro), Func, MS 宿主: 小鼠 Monoclonal W6-32 unconjugated
anti-MHC Class I Polypeptide-Related Sequence A (MICA) antibody (Biotin)MICA 适用: 人, Cow, Cat, Non-Human Primate ELISA, FACS, IP, ICC, IHC (fro) 宿主: 小鼠 Monoclonal W6-32 Biotin
anti-MHC Class I Polypeptide-Related Sequence A (MICA) antibody (FITC)MICA 适用: 人, Cow, Cat, Non-Human Primate FACS 宿主: 小鼠 Monoclonal W6-32 FITC
anti-MHC Class I Polypeptide-Related Sequence A (MICA) antibody (PE)MICA 适用: 人, Cow, Cat, Non-Human Primate FACS 宿主: 小鼠 Monoclonal W6-32 PE
anti-MHC Class I Polypeptide-Related Sequence A (MICA) antibody (PE)MICA 适用: 人 FACS 宿主: 小鼠 Monoclonal MEM-147 PE
anti-MHC Class I Polypeptide-Related Sequence A (MICA) (AA 24-307) antibodyMICA 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Flow cytometry: Recommended dilution: 1-12 μg/mL
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store at 2-8°C. Do not freeze.
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: "Expression of HLA-G in human cornea, an immune-privileged tissue." in: Human immunology, Vol. 64, Issue 11, pp. 1039-44, (2003) (PubMed).
: "The epitope recognized by pan-HLA class I-reactive monoclonal antibody W6/32 and its relationship to unusual stability of the HLA-B27/beta2-microglobulin complex." in: Immunogenetics, Vol. 53, Issue 6, pp. 440-6, (2001) (PubMed).
: "Residue 3 of beta2-microglobulin affects binding of class I MHC molecules by the W6/32 antibody." in: Immunogenetics, Vol. 49, Issue 4, pp. 312-20, (1999) (PubMed).
: "Mapping of the monoclonal antibody W6/32: sensitivity to the amino terminus of beta2-microglobulin." in: Tissue antigens, Vol. 51, Issue 5, pp. 567-70, (1998) (PubMed).
: "Reactivities of 20 anti-human monoclonal antibodies with leucocytes from ten different animal species." in: Veterinary immunology and immunopathology, Vol. 39, Issue 4, pp. 461-6, (1994) (PubMed).
: "Class I-like MHC molecules expressed by baboon placental syncytiotrophoblast." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 138, Issue 4, pp. 1088-91, (1987) (PubMed).
: "A biochemical characterization of feline MHC products: unusually high expression of class II antigens on peripheral blood lymphocytes." in: Immunogenetics, Vol. 23, Issue 5, pp. 341-7, (1986) (PubMed).
: "Evolution of HLA antigenic determinants: species cross-reactions of monoclonal antibodies." in: Immunogenetics, Vol. 15, Issue 2, pp. 151-66, (1982) (PubMed).
: "Production of monoclonal antibodies to group A erythrocytes, HLA and other human cell surface antigens-new tools for genetic analysis." in: Cell, Vol. 14, Issue 1, pp. 9-20, (1978) (PubMed).
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: "Expression of HLA-G in human cornea, an immune-privileged tissue." in: Human immunology, Vol. 64, Issue 11, pp. 1039-44, (2003) (PubMed).
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- MICA (MHC Class I Polypeptide-Related Sequence A (MICA))
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别名
- HLA Class I
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背景
- HLA-class I major histocompatibility (MHC) antigens are intrinsic membrane glycoproteins expressed on nucleated cells and noncovalently associated with an invariant beta2 microglobulin. They carry foreign determinants important for immune recognition by cytotoxic T cells, thus important for anti-viral and anti-tumour defence. Human HLA-class I antigens are represented by HLA-A, HLA-B and HLA-C molecules.
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途径
- Activation of Innate immune Response, Transition Metal Ion Homeostasis, Human Leukocyte Antigen (HLA) in Adaptive Immune Response
抗原
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