HLA-DR 抗体
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北京 101111
Quick Overview for HLA-DR 抗体 (ABIN2749036)
抗原
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Anti-HLA-DR Purified Low Endotoxin
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特异性
- The mouse monoclonal antibody L243 recognizes specifically an extracellular epitope on HLA-DR molecules, both peptide-loaded and empty.
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交叉反应 （详细）
- Human, Non-Human Primates, Canine (Dog)
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纯化方法
- Purified by protein-A affinity chromatography.
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纯度
- > 95 % (by SDS-PAGE)
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内毒素水平
- Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test.
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免疫原
- Human B lymphocytes
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亚型
- IgG2a kappa
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anti-HLA-DR (HLA-DR) antibody
HLA-DR 适用: 人 FACS, WB, IHC, ISt, StM 宿主: 小鼠 Monoclonal TAL 1B5 unconjugated
anti-HLA-DR (HLA-DR) antibody (FITC)HLA-DR 适用: 人 FACS 宿主: 小鼠 Monoclonal MEM-12 FITC
anti-HLA-DR (HLA-DR) antibodyHLA-DR 适用: 人 FACS, WB, IHC, IF, ISt, StM 宿主: 小鼠 Monoclonal SPM289 unconjugated
anti-HLA-DR (HLA-DR) antibodyHLA-DR 适用: 人, 犬, Non-Human Primate FACS, WB, IP, IHC (fro), IHC (p), ICC 宿主: 小鼠 Monoclonal L243 unconjugated
anti-HLA-DR (HLA-DR) antibodyHLA-DR 适用: 人 FACS, WB, IP 宿主: 小鼠 Monoclonal MEM-12 unconjugated
anti-HLA-DR (HLA-DR) antibody (PE)HLA-DR 适用: 人, 犬, Non-Human Primate FACS 宿主: 小鼠 Monoclonal L243 PE
anti-HLA-DR (HLA-DR) antibodyHLA-DR 适用: 人 FACS, IP 宿主: 小鼠 Monoclonal HL-39 unconjugated
anti-HLA-DR (HLA-DR) antibody (APC)HLA-DR 适用: 人 FACS 宿主: 小鼠 Monoclonal MEM-12 APC
anti-HLA-DR (HLA-DR) antibody (PE)HLA-DR 适用: 人 FACS 宿主: 小鼠 Monoclonal MEM-12 PE
anti-HLA-DR (HLA-DR) antibody (PerCP)HLA-DR 适用: 人 FACS 宿主: 小鼠 Monoclonal MEM-12 PerCP
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应用备注
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Functional application: Blocking.
Flow cytometry: Recommended dilution: 1-4 μg/mL -
限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH 7.4
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储存条件
- 4 °C
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储存方法
- Store at 2-8°C. Do not freeze.
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: "MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 9, pp. 3491-6, (2008) (PubMed).
: "Normal human kidney HLA-DR-expressing renal microvascular endothelial cells: characterization, isolation, and regulation of MHC class II expression." in: Journal of the American Society of Nephrology : JASN, Vol. 14, Issue 5, pp. 1336-48, (2003) (PubMed).
: "Lipid raft-dependent and -independent signaling through HLA-DR molecules." in: The Journal of biological chemistry, Vol. 278, Issue 9, pp. 7099-107, (2003) (PubMed).
: "Zwitterionic polysaccharides stimulate T cells by MHC class II-dependent interactions." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 169, Issue 11, pp. 6149-53, (2002) (PubMed).
: "Triggering of HLA-DR antigens differentially modulates tumor necrosis factor alpha release by B cells at distinct stage of maturation." in: Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, Vol. 8, Issue 5, pp. 581-8, (1997) (PubMed).
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: "MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 9, pp. 3491-6, (2008) (PubMed).
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- HLA-DR
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别名
- HLA-DR
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背景
- HLA-DR, a member of MHC class II glycoproteins, that bind intracellularly processed peptides and present them to the Th cells, is composed of 36 kDa alpha chain and 27 kDa beta chain, both anchored in the plasma membrane. Together with other MHC II molecules HLA-DR plays a central role in the immune system.
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途径
- Human Leukocyte Antigen (HLA) in Adaptive Immune Response
抗原
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