FLT1 抗体
Quick Overview for FLT1 抗体 (ABIN2745579)
抗原
See all FLT1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- The antibody will detect native human VEGFR-1/Flt-1 in ELISA experiments and on the surface of different human cell types.
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交叉反应
- 人
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纯化方法
- Protein G purified.
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免疫原
- Recombinant human soluble VEGFR-1.
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亚型
- IgG1
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anti-Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1) (AA 1162-1260) antibody
FLT1 适用: 人, 大鼠, 小鼠 WB, ELISA, FACS, ICC, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1) (AA 20-300) antibodyFLT1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1) (pTyr1213) antibodyFLT1 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1) (AA 1100-1200) antibodyFLT1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1) (AA 1-687) antibodyFLT1 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1) antibodyFLT1 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB16736 unconjugated
anti-Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1) (pTyr1048) antibodyFLT1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1) (AA 18-308) antibodyFLT1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1) (AA 1048-1328) antibodyFLT1 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1) (AA 1-380) antibodyFLT1 适用: 人 WB 宿主: 小鼠 Monoclonal 1453CT519-277-79 unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Centrifuge vial prior to opening. Reconstitute with sterile water to a concentration of 0.1-1.0 mg/mL.
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浓度
- Lot specific
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缓冲液
- Lyophilized.
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储存条件
- 4 °C,-20 °C
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储存方法
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Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C. -
有效期
- 6 months
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- FLT1 (Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1))
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别名
- VEGFR-1
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背景
- Recombinant human soluble vascular endothelial growth factor receptor-1 (sVEGFR-1) is the naturally occurring form and is a glycosylated monomeric protein. The biological function of sVEGFR-1 seems to be an endogenous regulator of angiogenesis, binding VEGF with the same affinity as the full-length receptor. VEGFR-1 is a tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis and cancer cell invasion. It may play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. It can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). It has a very high affinity for VEGFA and relatively low protein kinase activity. It may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Modulates KDR signaling by forming heterodimers with KDR. Ligand binding leads to the activation of several signaling cascades. Activation of phospholipase C-gamma (PLCG) leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates SRC and YES1 and may also phosphorylate CBL.
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UniProt
- P17948
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途径
- RTK signaling, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals
抗原
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