Rhodopsin 抗体
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Quick Overview for Rhodopsin 抗体 (ABIN272076)
抗原
See all Rhodopsin (RHO) 抗体宿主
克隆类型
标记
应用范围
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特异性
- This antibody detects endogenous levels of Rhodopsin protein. (region surrounding Leu328)
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交叉反应 （详细）
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Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. -
纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
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纯度
- > 95 % pure by SDS-PAGE
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anti-Rhodopsin (RHO) antibody
RHO 适用: Cow WB, IHC, ELISA, IP, ICC, IF 宿主: 小鼠 Monoclonal 1D4 unconjugated
anti-Rhodopsin (RHO) antibody (PerCP)RHO 适用: Cow WB, IHC, ELISA, IP, ICC, IF 宿主: 小鼠 Monoclonal 4D2 PerCP
anti-Rhodopsin (RHO) antibody (APC)RHO 适用: Cow WB, IHC, ELISA, IP, ICC, IF 宿主: 小鼠 Monoclonal 4D2 APC
anti-Rhodopsin (RHO) antibody (FITC)RHO 适用: Cow WB, IHC, ELISA, IP, ICC, IF 宿主: 小鼠 Monoclonal 4D2 FITC
anti-Rhodopsin (RHO) antibody (Biotin)RHO 适用: Cow WB, IHC, ELISA, IP, ICC, IF 宿主: 小鼠 Monoclonal 4D2 Biotin
anti-Rhodopsin (RHO) antibody (Atto 488)RHO 适用: Cow WB, IHC, ELISA, IP, ICC, IF 宿主: 小鼠 Monoclonal 4D2 Atto 488
anti-Rhodopsin (RHO) antibody (Atto 594)RHO 适用: Cow WB, IHC, ELISA, IP, ICC, IF 宿主: 小鼠 Monoclonal 4D2 Atto 594
anti-Rhodopsin (RHO) antibody (Atto 390)RHO 适用: Cow WB, IHC, ELISA, IP, ICC, IF 宿主: 小鼠 Monoclonal 4D2 Atto 390
anti-Rhodopsin (RHO) antibody (HRP)RHO 适用: Cow WB, IHC, ELISA, IP, ICC, IF 宿主: 小鼠 Monoclonal 4D2 HRP
anti-Rhodopsin (RHO) antibody (PE)RHO 适用: Cow WB, IHC, ELISA, IP, ICC, IF 宿主: 小鼠 Monoclonal 4D2 PE
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应用备注
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ELISA: 1: 1000approx. 1: 5000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1,0 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- DO NOT FREEZE!
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储存条件
- 4 °C
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储存方法
- Store the antibody undiluted at 2-8 °C.
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- Rhodopsin (RHO)
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别名
- Rhodopsin
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物质类
- Chemical
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背景
- Retinitis pigmentosa is an inherited progressive disease which is a major cause of blindness in western communities. It can be inherited as an autosomal dominant, autosomal recessive, or X linked recessive disorder. In the autosomal dominant form, which comprises about 25?% of total cases, approximately 30?% of families have mutations in the gene encoding the rod photoreceptor specific protein rhodopsin. This is the transmembrane protein which, when photoexcited, initiates the visual transduction cascade. Defects in this gene are also one of the causes of congenital stationary night blindness. Vision involves the conversion of light into electrochemical signals that are processed by the retina and subsequently sent to and interpreted by the brain. The process of converting light to an electrochemical signal begins when the membrane-bound protein, rhodopsin, absorbs light within the retina. Photoexcitation of rhodopsin causes the cytoplasmic surface of the protein to become catalytically active. In the active state, rhodopsin activates transducin, a GTP binding protein. Once activated, transducin promotes the hydrolysis of cGMP by phosphodiesterase (PDE). The decrease of intracellular cGMP concentrations causes the ion channels within the outer segment of the rod or cone to close, thus causing membrane hyperpolarization and, eventually, signal transmission. Rhodopsin's activity is believed to be shut off by its phosphorylation followed by binding of the soluble protein arrestin.Synonyms: OPN2, Opsin-2, RHO
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分子量
- approx. 42 kDa
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基因ID
- 6010
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NCBI登录号
- NP_000530
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UniProt
- P08100
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途径
- WNT signaling, Sensory Perception of Sound, Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction
抗原
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