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Rhodopsin 抗体 (Atto 488)

RHO 适用: Cow WB, IHC, ELISA, IP, ICC, IF 宿主: 小鼠 Monoclonal 4D2 Atto 488
产品编号 ABIN2482253
发货至: 中国
  • 抗原 See all Rhodopsin (RHO) 抗体
    Rhodopsin (RHO)
    适用
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    Cow
    宿主
    • 39
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    小鼠
    克隆类型
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    单克隆
    标记
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    This Rhodopsin antibody is conjugated to Atto 488
    应用范围
    • 51
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    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunofluorescence (IF)
    特异性
    Detects ~40 kDa. Binds specifically to the N-terminus of Rhodopsin. Does not detect Rhodopsin in invertebrates.
    交叉反应
    Amphibian, Avian, 鱼, 哺乳动物, Shark
    纯化方法
    Protein G Purified
    免疫原
    Bovine Rhodopsin
    克隆位点
    4D2
    亚型
    IgG1
    Top Product
    Discover our top product RHO Primary Antibody
  • 应用备注
    • WB (1:1000)
    • IHC (1000)
    • optimal dilutions for assays should be determined by the user.
    说明

    1 μg/ml of ABIN2482253 was sufficient for detection of rhodopsin in 10 μg of rat eye lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Conjugated antibodies should be stored at 4°C
  • 抗原
    Rhodopsin (RHO)
    别名
    Rhodopsin (RHO 产品)
    别名
    CSNBAD1 antibody, OPN2 antibody, RP4 antibody, RH1 antibody, Rh antibody, fi06d11 antibody, wu:fi06d11 antibody, zfo2 antibody, zfrho antibody, Noerg1 antibody, Opn2 antibody, Ops antibody, opn2 antibody, rh1 antibody, rp4 antibody, xrho antibody, PIGRHO1 antibody, ops antibody, RDP1 antibody, RHO antibody, rhodopsin antibody, rhodopsin L homeolog antibody, RHO antibody, Rho antibody, rho antibody, rho.L antibody
    物质类
    Chemical
    背景
    Rhodopsin consists of the protein moiety opsin and a reversibly covalently bound cofactor, retinal. Opsin, a bundle of seven membrane embedded alpha-helices, binds retinal, a photo reactive chromophore, in a central pocket (2, 3). In addition to being the pigment of the retina that is responsible for both the formation of the photoreceptor cells, its function is to specifically convey information stored in the specific geometry of the chormophore to the surface of the molecule upon light absorption (2). In the active state, rhodopsin activates transduction, a GTP binding protein. Once activated, transduction promotes the hydrolysis of cGMP by phosphodiesterase. Rhodopsin's activity is believed to be shut off by its phosphorylation followed by binding of the soluble protein arrestin (4). Mutations in the rhodopsin gene lead to retinitis pigmentosa, which can be inherited as an autosomal dominant, an autosomal recessive or an X-linked recessive disorder (5).
    基因ID
    509933
    NCBI登录号
    NP_001014890
    UniProt
    P02699
    途径
    WNT signaling, Sensory Perception of Sound, Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction
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