(5 references)-
- 抗原 See all ROR1 抗体
- ROR1 (Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR1))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This ROR1 antibody is un-conjugated
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应用范围
- Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 品牌
- BD Pharmingen™
- 产品特性
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The 4A5 monoclonal antibody binds to the glycosylated type I membrane protein ROR1 (Receptor-tyrosine-kinase-like Orphan Receptor 1). The ROR1 and ROR2 related proteins are highly conserved evolutionarily and are primarily expressed during embryogenesis. ROR1 is not expressed on normal peripheral blood lymphocytes. ROR1 is similar to tropomyosin receptor kinase (Trk family) neurotropic receptors and shares a cysteine-rich domain with Frizzled receptors for Wnt-family signaling proteins, which are involved in the regulation of embryogenesis and carcinogenesis. Furthermore, there is mounting evidence that aberrant ROR1 expression contributes to human malignancy. ROR1 expression in human embryonal carcinoma cells. Human NCCIT cells (ATCC CRL-2073) were stained with either Purified Mouse IgG2b κ Isotype Control (Cat. No. 555740, dashed line histogram) or Purified Mouse Anti-Human ROR1 (Cat. No. 564464, solid-line histogram) monoclonal antibodies. The second-step reagent was PE Goat Anti-Mouse Ig (Multiple Adsorption) (Cat. No. 550589). The fluorescence histograms were derived from events with the forward and side light-scatter characteristics of viable NCCIT cells. Flow cytometry was performed using a BD LSRFortessa™ Flow Cytometer System.
BD Pharmingen™ Purified Mouse Anti-Human ROR1 - Purified - Clone 4A5 - Isotype Mouse IgG2b, κ - Reactivity Hu - 0.1 mg - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Human ROR1 cDNA
- 克隆位点
- 4A5
- 亚型
- IgG2b kappa
- Top Product
- Discover our top product ROR1 Primary Antibody
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anti-Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR1) (AA 540-795) antibody
ROR1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR1) antibodyROR1 适用: 人, 小鼠 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR1) (AA 301-360) antibodyROR1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR1) (AA 470-707) antibodyROR1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR1) (AA 294-393) antibodyROR1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1B4 unconjugated
anti-Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR1) (AA 112-399) antibodyROR1 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR1) (C-Term) antibodyVerified ROR1 适用: 人 ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR1) antibodyROR1 适用: 人, 小鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB14753 unconjugated
anti-Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR1) antibodyROR1 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR1) (N-Term) antibodyROR1 适用: 人 WB, FACS 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 浓度
- 0.5 mg/mL
- 缓冲液
- Aqueous buffered solution containing ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Store undiluted at 4°C.
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: "Targeting ROR1 inhibits epithelial-mesenchymal transition and metastasis." in: Cancer research, Vol. 73, Issue 12, pp. 3649-60, (2013) (PubMed).
: "The onco-embryonic antigen ROR1 is expressed by a variety of human cancers." in: The American journal of pathology, Vol. 181, Issue 6, pp. 1903-10, (2012) (PubMed).
: "ROR1 is expressed in human breast cancer and associated with enhanced tumor-cell growth." in: PLoS ONE, Vol. 7, Issue 3, pp. e31127, (2012) (PubMed).
: "ROR1 is expressed on hematogones (non-neoplastic human B-lymphocyte precursors) and a minority of precursor-B acute lymphoblastic leukemia." in: Leukemia research, Vol. 35, Issue 10, pp. 1390-4, (2011) (PubMed).
: "Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 8, pp. 3047-52, (2008) (PubMed).
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: "Targeting ROR1 inhibits epithelial-mesenchymal transition and metastasis." in: Cancer research, Vol. 73, Issue 12, pp. 3649-60, (2013) (PubMed).
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- 抗原
- ROR1 (Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR1))
- 别名
- ROR1 (ROR1 产品)
- 别名
- NTRKR1 antibody, dJ537F10.1 antibody, 2810404D04Rik antibody, Ntrkr1 antibody, mRor1 antibody, RGD1559469 antibody, ROR1 antibody, fi34e02 antibody, si:dkey-209n16.1 antibody, wu:fi34e02 antibody, receptor tyrosine kinase like orphan receptor 1 antibody, receptor tyrosine kinase-like orphan receptor 1 antibody, ROR1 antibody, Ror1 antibody, ror1 antibody
- 背景
- Synonyms: Neurotrophic tyrosine kinase, receptor-related 1, NTRKR1
- 途径
- RTK signaling, WNT signaling, Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha
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