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CD40 Ligand 抗体

CD40LG 适用: 人, 猕猴, Baboon, Cynomolgus FACS 宿主: 小鼠 Monoclonal TRAP1 unconjugated
产品编号 ABIN2688992
发货至: 中国
  • 抗原 See all CD40 Ligand (CD40LG) 抗体
    CD40 Ligand (CD40LG)
    适用
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    人, 猕猴, Baboon, Cynomolgus
    宿主
    • 87
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    小鼠
    克隆类型
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    单克隆
    标记
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    This CD40 Ligand antibody is un-conjugated
    应用范围
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    Flow Cytometry (FACS)
    品牌
    BD Pharmingen™
    产品特性
    Reacts with CD40 ligand (CD40L), a 39 kDa type II membrane glycoprotein expressed on activated T cells. CD40-CD40L interaction plays a very important role in T cell-dependent B-cell proliferation, differentiation, and memory cell formation. Anti-CD40L mAb partially blocks T cell-B cell interaction affecting subsequent proliferation, differentiation, and memory cell formation. Anti-CD40L mAb partially blocks T cell-B cell interaction affecting subsequent proliferation, IL-2R expression and differentiation of B cells. In addition, blocking of CD40-CD40L interaction has been demonstrated with soluble CD40, resulting in the inhibition of immunoglobulin isotype switching. It has been reported that patients with X-linked hyper-IgM syndrome have defective expression of functional CD40L due to a defective gene that encodes CD40L. This antibody is routinely tested by flow cytometric analysis. Other applications were tested during antibody development only or reported in the literature. Profile of TPA+Ca++ Ionophore-stimulated PBMCs analyzed on a FACScan

    BD Pharmingen™ Purified Mouse Anti-Human CD154 - Purified - Clone TRAP1 (also known as TRAP-1) - Isotype Mouse IgG1, κ - Reactivity Hu, Bab, Cyno, Rhe - 0.1 mg
    纯化方法
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    克隆位点
    TRAP1
    亚型
    IgG1 kappa
    Top Product
    Discover our top product CD40LG Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 浓度
    0.5 mg/mL
    缓冲液
    Aqueous buffered solution containing ≤0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Store undiluted at 4°C.
  • Fuleihan, Ramesh, Horner, Ahern, Belshaw, Alberg, Stamenkovic, Harmon, Geha: "Cyclosporin A inhibits CD40 ligand expression in T lymphocytes." in: The Journal of clinical investigation, Vol. 93, Issue 3, pp. 1315-20, (1994) (PubMed).

    Gray, Dullforce, Jainandunsing: "Memory B cell development but not germinal center formation is impaired by in vivo blockade of CD40-CD40 ligand interaction." in: The Journal of experimental medicine, Vol. 180, Issue 1, pp. 141-55, (1994) (PubMed).

    Nishioka, Lipsky: "The role of CD40-CD40 ligand interaction in human T cell-B cell collaboration." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 153, Issue 3, pp. 1027-36, (1994) (PubMed).

    van Kooten, Gaillard, Galizzi, Hermann, Fossiez, Banchereau, Blanchard: "B cells regulate expression of CD40 ligand on activated T cells by lowering the mRNA level and through the release of soluble CD40." in: European journal of immunology, Vol. 24, Issue 4, pp. 787-92, (1994) (PubMed).

  • 抗原
    CD40 Ligand (CD40LG)
    别名
    CD154 (CD40LG 产品)
    别名
    CD154 antibody, cd40l antibody, CD40L antibody, HIGM1 antibody, IGM antibody, IMD3 antibody, T-BAM antibody, TNFSF5 antibody, TRAP antibody, gp39 antibody, hCD40L antibody, CD40-L antibody, Cd40l antibody, Ly-62 antibody, Ly62 antibody, Tnfsf5 antibody, CD40 ligand antibody, TNF superfamily member 5 antibody, CD40LG antibody, cd40l antibody, Cd40lg antibody
    背景
    Synonyms: CD40L
    途径
    NF-kappaB Signaling, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints
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