CD40 Ligand 抗体
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北京 101111
Quick Overview for CD40 Ligand 抗体 (ABIN2688992)
抗原
See all CD40 Ligand (CD40LG) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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产品特性
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Reacts with CD40 ligand (CD40L), a 39 kDa type II membrane glycoprotein expressed on activated T cells. CD40-CD40L interaction plays a very important role in T cell-dependent B-cell proliferation, differentiation, and memory cell formation. Anti-CD40L mAb partially blocks T cell-B cell interaction affecting subsequent proliferation, differentiation, and memory cell formation. Anti-CD40L mAb partially blocks T cell-B cell interaction affecting subsequent proliferation, IL-2R expression and differentiation of B cells. In addition, blocking of CD40-CD40L interaction has been demonstrated with soluble CD40, resulting in the inhibition of immunoglobulin isotype switching. It has been reported that patients with X-linked hyper-IgM syndrome have defective expression of functional CD40L due to a defective gene that encodes CD40L. This antibody is routinely tested by flow cytometric analysis. Other applications were tested during antibody development only or reported in the literature. Profile of TPA+Ca++ Ionophore-stimulated PBMCs analyzed on a FACScan
BD Pharmingen™ Purified Mouse Anti-Human CD154 - Purified - Clone TRAP1 (also known as TRAP-1) - Isotype Mouse IgG1, κ - Reactivity Hu, Bab, Cyno, Rhe - 0.1 mg -
纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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亚型
- IgG1 kappa
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anti-CD40 Ligand (CD40LG) (AA 1-261) antibody
CD40LG 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-CD40 Ligand (CD40LG) (AA 108-261) antibodyCD40LG 适用: 人 FACS, IHC, ELISA, IF, Coat, StM 宿主: 小鼠 Monoclonal CD40LG-2761 unconjugated
anti-CD40 Ligand (CD40LG) (AA 108-261) antibodyCD40LG 适用: 人 FACS, IHC, ELISA, IF, Coat, StM 宿主: 小鼠 Monoclonal CD40LG-2763 unconjugated
anti-CD40 Ligand (CD40LG) antibody (FITC)CD40LG 适用: 小鼠 FACS 宿主: 仓鼠 Monoclonal MR-1 FITC
anti-CD40 Ligand (CD40LG) (AA 33-62) antibodyCD40LG 适用: 人 WB, FACS, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-CD40 Ligand (CD40LG) (AA 111-261) antibodyCD40LG 适用: Pig WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-CD40 Ligand (CD40LG) antibody (PE)CD40LG 适用: 人, Non-Human Primate FACS 宿主: 小鼠 Monoclonal 24-31 PE
anti-CD40 Ligand (CD40LG) (AA 47-261) antibodyCD40LG 适用: 人 FACS, ELISA 宿主: 小鼠 Monoclonal 5A3A9 unconjugated
anti-CD40 Ligand (CD40LG) (AA 47-261) antibodyCD40LG 适用: 人 FACS, ELISA 宿主: 小鼠 Monoclonal 8H10F5 unconjugated
anti-CD40 Ligand (CD40LG) (AA 47-65), (N-Term) antibodyCD40LG 适用: 人, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- Aqueous buffered solution containing ≤0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store undiluted at 4°C.
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: "Cyclosporin A inhibits CD40 ligand expression in T lymphocytes." in: The Journal of clinical investigation, Vol. 93, Issue 3, pp. 1315-20, (1994) (PubMed).
: "Memory B cell development but not germinal center formation is impaired by in vivo blockade of CD40-CD40 ligand interaction." in: The Journal of experimental medicine, Vol. 180, Issue 1, pp. 141-55, (1994) (PubMed).
: "The role of CD40-CD40 ligand interaction in human T cell-B cell collaboration." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 153, Issue 3, pp. 1027-36, (1994) (PubMed).
: "B cells regulate expression of CD40 ligand on activated T cells by lowering the mRNA level and through the release of soluble CD40." in: European journal of immunology, Vol. 24, Issue 4, pp. 787-92, (1994) (PubMed).
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: "Cyclosporin A inhibits CD40 ligand expression in T lymphocytes." in: The Journal of clinical investigation, Vol. 93, Issue 3, pp. 1315-20, (1994) (PubMed).
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- CD40 Ligand (CD40LG)
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别名
- CD154
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背景
- Synonyms: CD40L
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途径
- NF-kappaB Signaling, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints
抗原
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